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bisindolylmaleimide I

a bis(indolyl)maleimide
Also Known As:
2-(1-(3-dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide; 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; BIS-1 cpd; GF 109203X; GF-109203X; GF109203X; GFX 203290; Go 6850; Go-6850; bisindoylmaleimide I; 1H-Pyrrole-2,5-dione, 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-
Networked: 106 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Darmani, Nissar A: 3 articles (01/2021 - 09/2018)
2. Zhong, Weixia: 3 articles (01/2021 - 09/2018)
3. Denizalti, Merve: 2 articles (11/2018 - 11/2017)
4. Durlu-Kandilci, Nezahat Tugba: 2 articles (11/2018 - 11/2017)
5. Sahin-Erdemli, Inci: 2 articles (11/2018 - 11/2017)
6. Ferreira, Juliano: 2 articles (08/2011 - 08/2006)
7. Calixto, João B: 2 articles (11/2010 - 08/2006)
8. Fry, Christopher H: 2 articles (01/2009 - 03/2008)
9. Roosen, Alexander: 2 articles (01/2009 - 03/2008)
10. Wu, Changhao: 2 articles (01/2009 - 03/2008)

Related Diseases

1. Hyperalgesia
2. Neoplasms (Cancer)
3. Ischemia
08/01/1998 - "Infusion of a specific PKC inhibitor GF109203X(GF) at 30 or 300 nmol/L, starting from 5 min before ischemia and maintained throughout ischemia concomitantly with 10 mumol/L of PE, was partially effective in reducing VF incidence; which reduced from 75% in control to 42% with 300 nmol/L of GF. "
08/01/2007 - "The rabbits are randomly divided into 3 groups (n = 8 in each group): (1) Ischemia-reperfusion (IR): LADO and reperfusion without additional intervention; (2) RI-Post: after 60 minutes of LADO, the left renal artery was occluded for 30 seconds and reperfused for 30 seconds and repeated 3 times, then the coronary artery was reperfused for 6 hours; (3) Medication intervention (MI): 10 minutes before coronary reperfusion, rabbits were treated with PKC antagonist GF109203X (0.05 mg/kg, IV), followed by RI-Post treatment and 6 hours coronary reperfusion. "
04/01/1998 - "Exogenous CaCl2 (3.0 mmol/L for 5 minutes) or vehicle (saline solution) was administered before simulated ischemia, with or without concurrent PKC inhibition (bisindolylmaleimide I, 150 nmol/L). "
06/25/2011 - "After ischemia-reperfusion, the vasodilatation to Ap4A diminished, both in hearts with basal or increased vascular tone, and in this case the relaxation to Ap4A was not modified by reactive blue 2, L-NAME, glibenclamide, isatin, H89, GF109203x or wortmannin, although it was reduced by U73122 and endothelin-1. "
06/01/2005 - "After 6-hydroxydopamine (6-OHDA) pretreatment and a 20-min stabilization period, hearts were perfused at constant pressure for 20 min then subjected to 40 min of global ischemia and 30 min of reperfusion (I/R, Ctrl); exposed to 0.01 microM XA for 5 min with or without 10 microM atenolol (ATE), a specific antagonist of beta1-AR, followed by a 15-min XA-free perfusion before I/R (PC, ATE-PC, respectively); treated during 20 min with either phosphoinositide (PI) 3-kinase inhibitors, LY-294002 (LY, 15 microM), or wortmaninn (WO, 0.1 microM); protein kinase C (PKC) inhibitor, GF-109203X (GF, 4 nM); or protein kinase A (PKA) inhibitor, H89 (H89, 1 microM), with an infusion starting 3 min before XA (LY-PC, WO-PC, GF-PC, and H89-PC, respectively). "
4. Hypoxia (Hypoxemia)
5. Pain (Aches)

Related Drugs and Biologics

1. chelerythrine
2. Sirolimus (Rapamycin)
3. Formaldehyde (Formol)
4. N- alpha- benzoyl- N5- (2- chloro- 1- iminoethyl)- L- ornithine amide
5. Protein Kinase C
6. bisindolylmaleimide I
7. 2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- one
8. Staurosporine
9. rottlerin
10. Wortmannin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Catheters
3. Transplantation
4. Intraperitoneal Injections
5. Intra-Articular Injections