|1.||Chen, D: 1 article (07/2014)|
|2.||Yu, S P: 1 article (07/2014)|
|3.||Song, M: 1 article (07/2014)|
|4.||Rodrigues, Elaine G: 1 article (05/2014)|
|5.||Bechara, Alexandre: 1 article (05/2014)|
|6.||Caires, Antonio C F: 1 article (05/2014)|
|7.||Barbosa, Christiano M V: 1 article (05/2014)|
|8.||Matsuo, Alisson L: 1 article (05/2014)|
|9.||Nascimento, Fábio D: 1 article (05/2014)|
|10.||Paredes-Gamero, Edgar J: 1 article (05/2014)|
08/22/2015 - "Moreover, PC-EEF-caused cytotoxicity, membrane damage, mitochondrial injury and apoptosis were remarkably reversed by BAPTA-AM. PC-EEF damaged the membrane system and triggered Ca(2+)-dependent mitochondrial apoptosis, which may provide some new insights into its efficacy against human leukemia cells."
08/22/2015 - "The role of Ca(2+) in PC-EEF-induced cell death was investigated by Ca(2+) chelating reagent BAPTA-AM. PC-EEF possessed relatively high flavonoid content (about 88.84 ± 0.89%) and showed significant cytotoxicity to human leukemia cells. "
01/01/1995 - "The permeant Ca2+ chelator acetoxymethyl-1,2-bis(2-aminopheoxy)ethane- N,N,N',N'-tetraacetic acid (BAPTA/AM), an agent previously used to characterize drug-induced apoptosis in neoplastic cells, has been examined with respect to induction of DNA fragmentation and cytotoxicity in the human leukemia cell lines HL-60 and U937. "
08/01/1998 - "In the present study, we have investigated the consequences of buffering intracellular calcium with 1,2-bis(o-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetra(acetoxy-methyl) ester (BAPTA-AM) on the sensitizing effects of the calmodulin-dependent protein kinase II inhibitor 1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-piperazine (KN-62) in etoposide-resistant human leukemia HL-60 (HL-60/ADR0.05) cells. "
|2.||Brain Ischemia (Cerebral Ischemia)
11/15/2010 - "BAPTA free acid was identified as the main metabolic product of 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(actoxymethyl ester) (BAPTA-AM), a neuroprotective agent in cerebral ischemia, in rats. "
11/01/1994 - "Cell-permeant Ca2+ chelators such as 1,2-bis-(2-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid acetoxymethyl ester (BAPTA-AM) have been reported to protect neurons in experimental focal cerebral ischemia. "
12/01/2006 - "BAPTA-AM is the acetoxymethylester of the calcium chelator BAPTA and has demonstrated efficacy in several animal models of cerebral ischemia. "
|3.||Ganglion Cysts (Ganglion)
03/01/2009 - "Here we show that transient localized depolarization of these axons in an excised nerve-ganglion preparation or in dissociated cell culture can induce short- and intermediate-term axonal hyperexcitability as well as long-term protein synthesis-dependent hyperexcitability under conditions in which Ca(2+) entry is prevented (by bathing in nominally Ca(2+) -free solutions containing EGTA) and detectable Ca(2+) transients are eliminated (by adding BAPTA-AM). "
09/01/2008 - "Histological analysis of retinal ischemic slices showed 40% reduction of ganglion cells that was prevented by BAPTA-AM or dantrolene. "
|4.||Lung Neoplasms (Lung Cancer)
11/20/2009 - "BAPTA-AM is highly effective in the inhibition of GRP78, down-regulation of GRP78 can significantly increase the sensitivity of adenocacinoma lung cancer to VP-16. "
11/20/2009 - "All these suggest that inhibition of the expression of GRP78 by chemicals such as BAPTA-AM or anti-sense RNA may be a new therapeutic strategies to lung cancer."
01/01/2010 - "IPA-induced apoptosis was substantially reduced in the presence of an intracellular calcium chelator BAPTA/AM. Taken together, these results suggest that both mitochondrial dysfunction and ER stress contribute to IPA-induced apoptosis of human cervical cancer HeLa cells."
11/01/2009 - "MTD peptide-induced cell death can be inhibited by calcium chelator BAPTA-AM. Moreover, MTD peptide shows the potent tumor-killing activities in mice by joining with tumor-homing motifs."
12/15/2004 - "By contrast, BAPTA-am exerted its effects via inhibition of HIF-prolyl hydroxylase activity and von Hippel-Lindau tumor repressor protein (VHL) interaction. "
09/01/2008 - "After SGC-7901 cell being treated by Wuxing soup, it showed that: 1) Wuxing soup could specifically inhibit cancer cells proliferation in a time and dose dependent manner; 2) Typical apoptotic morphological changes and DNA ladder of SGC-7901 cells were observed; 3) calcium inhibitor Bapta AM could reduce the apoptotic rate and protect SGC-7901 cells in a dose dependent manner. "
02/01/2010 - "In the present study two cell lines (normal human liver cell HL-7702, and tumor cell Raji cell) were exposed to Cd along or co-incubated with ethylene glycol-bis (2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA) and 1,2-bis (2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-acetoxymethyl ester (BAPTA-AM), respectively. "
|2.||Egtazic Acid (EGTA)
|3.||Etoposide (VP 16)
|4.||1,2- bis(2- aminophenoxy)ethane- N,N,N',N'- tetraacetic acid (BAPTA)
|6.||Calcium-Calmodulin-Dependent Protein Kinase Type 2
|7.||Glutamic Acid (Glutamate)
|8.||Dizocilpine Maleate (Dizocilpine)
|10.||Nitric Oxide (Nitrogen Monoxide)