NIP 121

structure given in first source

Also Known As:

7,8-dihydro-6,6-dimethyl-7-hydroxy-8-(2-oxo-piperidin-1-yl)-6H-pyrano(2,3)benz-2,1,3-oxadiazole; NIP-121; 2-Piperidinone, 1-(7,8-dihydro-7-hydroxy-6,6-dimethyl-6H-pyrano(2,3-f)-2,1,3-benzoxadiazol-8-yl)-, trans-(+)-

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        NIP 121: 3
  - Piperidines: 17
    - NIP 121: 3

Related Diseases

1.	Ischemia 05/01/1996 - "We demonstrated that NIP-121 may have protective effects against myocardial injury during ischemia and reperfusion. " 05/01/1996 - "NIP-121 was also shown to attenuate the decrease in tissue ATP during ischemia and reperfusion. " 05/01/1996 - "The preparations were subjected to 30-min no-flow ischemia with or without NIP-121 or glibenclamide, followed by 60-min reperfusion. " 05/01/1996 - "We investigated the effect of NIP-121, a novel ATP-sensitive K+ channel opener, on myocardial damage during ischemia/reperfusion. " 05/01/1996 - "Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea pig myocardium."
2.	Pulmonary Hypertension 09/01/1993 - "NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension." 09/01/1993 - "To determine if NIP-121, a new antihypertensive agent with K+ channel-opening activity, would be an effective vasodilator in pulmonary hypertension, we studied its acute hemodynamic effects under normoxic conditions in conscious chronically hypoxic pulmonary hypertensive rats and in control pulmonary normotensive rats. " 09/01/1993 - "These results show that in contrast to the Ca2+ channel blocker, nifedipine, the K+ channel activator, NIP-121, is a potent vasodilator of chronic hypoxia-induced pulmonary hypertension in the rat. "
3.	Hypotension (Low Blood Pressure) 08/01/1991 - "The ED20 values for hypotension by NIP-121, cromakalim, and lemakalim were 0.017, 0.040, and 0.016 mg/kg, respectively. "
4.	Hypoxia (Hypoxemia) 09/01/1993 - "These results show that in contrast to the Ca2+ channel blocker, nifedipine, the K+ channel activator, NIP-121, is a potent vasodilator of chronic hypoxia-induced pulmonary hypertension in the rat. "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	KATP Channels
3.	Cromakalim (Levcromakalim)
4.	Vasodilator Agents (Vasodilators)
5.	Glyburide (Glibenclamide)
6.	Antihypertensive Agents (Antihypertensives)
7.	Adenosine Triphosphate (ATP)