alglucerase

modified form of human placental glucocerebrosidase; oligosaccharide units of glucocerebrosidase are sequentially deglycosylated to yield a mannose-terminated preparation which is targeted to the mannose lectin on the macrophage plasma membrane

Also Known As:

Networked: 67 relevant articles (10 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Charrow, Joel: 4 articles (01/2021 - 02/2009)
2.	Belmatoug, Nadia: 3 articles (01/2021 - 01/2002)
3.	Kaplan, Paige: 3 articles (09/2017 - 12/2008)
4.	Zimran, Ari: 3 articles (09/2014 - 02/2009)
5.	vom Dahl, Stephan: 3 articles (05/2013 - 02/2009)
6.	Weinreb, Neal J: 2 articles (01/2021 - 05/2013)
7.	Mistry, Pramod K: 2 articles (09/2017 - 02/2009)
8.	Cole, J Alexander: 2 articles (05/2013 - 02/2009)
9.	Germain, D P: 2 articles (12/2010 - 11/2001)
10.	Kacena, Katherine: 2 articles (02/2009 - 12/2008)

Related Diseases

1.	Gaucher Disease (Gaucher's Disease) 01/01/1992 - "The FDA recently approved Ceredase, a new treatment for Gaucher's disease, under the provisions of the Orphan Drug Act. " 02/01/2003 - "A 19-year-old male patient with type 1 Gaucher disease was put on regular biweekly infusions of alglucerase. " 12/01/1998 - "Alglucerase treatment of type 1 Gaucher disease with pulmonary involvement." 12/01/1998 - "[Persistence of pulmonary lesions in a 6-year-old boy with type I Gaucher's disease treated by alglucerase since the age of 20 months]." 01/01/1998 - "Alglucerase: practical guidance on appropriate dosage and administration in patients with Gaucher disease."
2.	Fabry Disease (Fabry's Disease) 04/01/2006 - "The spectacular clinical and financial success of Cerezyme (and previously Ceredase, Genzyme) for the treatment of Gaucher disease has led to the development of enzyme replacement treatment(s) for Fabry disease and mucopolysaccharidoses types I and VI. A number of other enzyme replacement therapies are at an earlier stage in development and the next 12 months could see the launch of therapies for mucopolysaccharidosis type II and Pompe disease. " 12/01/2010 - "Extraction and purification of an acid β-glucosidase from human placenta (alglucerase) for the treatment of Gaucher disease, replaced a few years later by a recombinant enzyme (imiglucérase, Cerezyme(®)), has paved the way to the development of enzyme replacement therapies (ERT) for the treatment of lysosomal storage diseases (LSD) among which Fabry disease for which the long-term efficacy of the two currently available preparations (agalsidase alfa, Replagal(®) and Fabrazyme(®)) is still being investigated. "
3.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 12/01/2010 - "Extraction and purification of an acid β-glucosidase from human placenta (alglucerase) for the treatment of Gaucher disease, replaced a few years later by a recombinant enzyme (imiglucérase, Cerezyme(®)), has paved the way to the development of enzyme replacement therapies (ERT) for the treatment of lysosomal storage diseases (LSD) among which Fabry disease for which the long-term efficacy of the two currently available preparations (agalsidase alfa, Replagal(®) and Fabrazyme(®)) is still being investigated. "
4.	Thrombocytopenia (Thrombopenia) 01/01/2001 - "Enzyme replacement therapy with alglucerase prevented further deterioration and improved thrombocytopenia. "
5.	Neurologic Manifestations (Neurological Manifestations) 01/01/2002 - "Patients with Gaucher disease have been classified in three types: type I is the more common, neurological manifestations occur in types II and III. Enzyme replacement therapy (ERT) with modified placental human glucocerebrosidase (ceredase) or recombinant glucocerebrosidase (cerezyme) is effective in most type I Gaucher disease and has become the current standard care administered to thousand of patients worldwide. "

Related Drugs and Biologics

1.	alglucerase
2.	imiglucerase
3.	Enzymes
4.	Glucosylceramidase (Glucocerebrosidase)
5.	Mannose (D-Mannose)
6.	Glucosidases
7.	Lysergic Acid Diethylamide (LSD)
8.	Acids
9.	agalsidase beta
10.	agalsidase alfa

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Therapeutics
3.	Enzyme Therapy
4.	Intravenous Administration
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)