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RG 13022

structure given in first source

Also Known As:

RG-13022; 3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Tyrphostins: 183
        RG 13022: 3
- Nitriles: 227
  - Tyrphostins: 183
    - RG 13022: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - Tyrphostins: 183
        RG 13022: 3

Related Diseases

1.	Neoplasms (Cancer) 08/15/1991 - "RG-13022 also increased the life span of these tumor-bearing nude mice. " 07/01/1992 - "To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022, on cultured human breast cancer cells. " 03/01/1996 - "To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022 (tyrphostin), on cultured human prostate cancer cells. "
2.	Prostatic Neoplasms (Prostate Cancer) 03/01/1996 - "To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022 (tyrphostin), on cultured human prostate cancer cells. "
3.	Breast Neoplasms (Breast Cancer) 07/01/1992 - "The TK inhibitor RG-13022 is a potent inhibitor of hormonally regulated growth of human breast cancer. " 07/01/1992 - "To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022, on cultured human breast cancer cells. " 07/01/1992 - "RG-13022 also inhibited EGF-stimulated DNA synthesis and proliferation of T47D and MCF-7 breast cancer cells in a reversible and dose-dependent manner. " 07/01/1992 - "RG-13022 significantly inhibited EGF-stimulated autophosphorylation of its receptor in two breast cancer cell lines that have abundant, although not amplified, EGF receptor content (MDA-231 and T47D). "

Related Drugs and Biologics

1.	Tyrosine Kinase Inhibitors
2.	ErbB Receptors (EGF Receptor)
3.	Tyrphostins
4.	Epidermal Growth Factor (EGF)
5.	DNA (Deoxyribonucleic Acid)