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RG 13022
structure given in first source
Also Known As:
RG-13022; 3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzylidene Compounds: 10
Tyrphostins: 183
RG 13022: 3
Nitriles: 227
Tyrphostins: 183
RG 13022: 3
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinoxalines: 324
Tyrphostins: 183
RG 13022: 3
Related Diseases
1.
Neoplasms (Cancer)
08/15/1991 - "
RG-13022 also increased the life span of these tumor-bearing nude mice.
"
07/01/1992 - "
To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022, on cultured human breast cancer cells.
"
03/01/1996 - "
To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022 (tyrphostin), on cultured human prostate cancer cells.
"
2.
Prostatic Neoplasms (Prostate Cancer)
03/01/1996 - "
To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022 (tyrphostin), on cultured human prostate cancer cells.
"
3.
Breast Neoplasms (Breast Cancer)
07/01/1992 - "
The TK inhibitor RG-13022 is a potent inhibitor of hormonally regulated growth of human breast cancer.
"
07/01/1992 - "
To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied the effects of a tyrosine kinase inhibitor, RG-13022, on cultured human breast cancer cells.
"
07/01/1992 - "
RG-13022 also inhibited EGF-stimulated DNA synthesis and proliferation of T47D and MCF-7 breast cancer cells in a reversible and dose-dependent manner.
"
07/01/1992 - "
RG-13022 significantly inhibited EGF-stimulated autophosphorylation of its receptor in two breast cancer cell lines that have abundant, although not amplified, EGF receptor content (MDA-231 and T47D).
"
Related Drugs and Biologics
1.
Tyrosine Kinase Inhibitors
2.
ErbB Receptors (EGF Receptor)
3.
Tyrphostins
4.
Epidermal Growth Factor (EGF)
5.
DNA (Deoxyribonucleic Acid)