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R 47243

RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 9/91

Also Known As:

R 47 243; R 47243, (+)-isomer; R 47243, (-)-isomer; R 62 651; R 62651; R-47 243; R-47243; R-62 651; R-62651

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - R 47243: 1
  - Piperidines: 17
    - R 47243: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - R 47243: 1

Related Diseases

1.

Tremor (Tremors)

04/01/1991 - "Treatment with the racemic alpha 2 antagonist R 47 243 of a monkey with MPTP-induced parkinsonian signs normalized blink rate, reduced resting tremor, and improved several other parkinsonian signs. "
04/01/1991 - "In a second experiment, the (-)-isomer R 62 651 produced a gradual change in tremor which was the inverse of the mannner in which tremor had become installed as the result of progression earlier upon the MPTP challenge. "

Related Drugs and Biologics

1.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)