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tryptase TL(2)

binds specifically to the external envelope protein of gp120 of HIV-1, interacting with its V3 domain

Also Known As:

tryptase TL2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Tryptases: 2102
        tryptase TL(2): 3
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Tryptases: 2102
        tryptase TL(2): 3

Related Diseases

1.	HIV Infections (HIV Infection) 04/01/1996 - "To investigate the role of tryptase TL2 in HIV infection, we examined the affinity of the interaction and the proteolytic susceptibility of various recombinant gp120 expressed in mammalian cells to the enzyme, and we determined the cleavage sites. "
2.	Human Influenza (Influenza) 01/01/1996 - "Here we described the host cellular processing proteases, tryptase Clara and tryptase TL2, which proteolytically activate the infectivity of influenza A and Sendai viruses in the respiratory tract and HIV-1 in human CD4+ T cells, respectively. "
3.	Infections 01/01/1991 - "These findings suggest that tryptase TL2 is important in target site recognition and binding of HIV-1 in co-operation with CD4 receptor in the initial process of HIV-1 infection."

Related Drugs and Biologics

1.	CD4 Antigens (CD4 Antigen)
2.	Peptide Hydrolases (Proteases)
3.	Enzymes
4.	tryptase Clara