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tryptase TL(2)
binds specifically to the external envelope protein of gp120 of HIV-1, interacting with its V3 domain
Also Known As:
tryptase TL2
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Peptide Hydrolases: 23957
Serine Proteases: 3726
Serine Endopeptidases: 11
Tryptases: 2102
tryptase TL(2): 3
Endopeptidases: 633
Serine Endopeptidases: 11
Tryptases: 2102
tryptase TL(2): 3
Related Diseases
1.
HIV Infections (HIV Infection)
04/01/1996 - "
To investigate the role of tryptase TL2 in HIV infection, we examined the affinity of the interaction and the proteolytic susceptibility of various recombinant gp120 expressed in mammalian cells to the enzyme, and we determined the cleavage sites.
"
2.
Human Influenza (Influenza)
01/01/1996 - "
Here we described the host cellular processing proteases, tryptase Clara and tryptase TL2, which proteolytically activate the infectivity of influenza A and Sendai viruses in the respiratory tract and HIV-1 in human CD4+ T cells, respectively.
"
3.
Infections
01/01/1991 - "
These findings suggest that tryptase TL2 is important in target site recognition and binding of HIV-1 in co-operation with CD4 receptor in the initial process of HIV-1 infection.
"
Related Drugs and Biologics
1.
CD4 Antigens (CD4 Antigen)
2.
Peptide Hydrolases (Proteases)
3.
Enzymes
4.
tryptase Clara