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topsentin

structure given in first source; a marine natural product

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - topsentin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - topsentin: 4

Experts

1.	Parrino, Barbara: 3 articles (12/2021 - 02/2013)
2.	Carbone, Daniela: 2 articles (12/2021 - 01/2021)
3.	Cascioferro, Stella: 2 articles (12/2021 - 01/2021)
4.	Diana, Patrizia: 2 articles (12/2021 - 01/2021)
5.	Giovannetti, Elisa: 2 articles (12/2021 - 01/2021)
6.	Pecoraro, Camilla: 2 articles (12/2021 - 01/2021)
7.	Avan, Amir: 1 article (12/2021)
8.	Peters, Godefridus J: 1 article (12/2021)
9.	Puerta, Adrian: 1 article (12/2021)
10.	Auriemma, Giulia: 1 article (01/2021)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2021 - "1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase." 12/21/2021 - "A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells."
2.	Inflammation (Inflammations) 01/29/2020 - "However, the effect of topsentin on skin inflammation and its underlying molecular mechanism has not been elucidated. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/26/2013 - "Derivatives 10a,c-e, deazaanalogues of the bis-indole alkaloid topsentin, screened by the National Cancer Institute (Bethesda, MD, USA) in the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity, with the exception of compound 9e, which showed moderate activity against the HOP-92 cell line of the non small cell lung cancer sub-panel and the SNB-75 cell line of the CNS sub-panel."

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