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NPC 16731
RN from Toxlit; bradykinin antagonist
Also Known As:
Arg(Hyp(3)-Thi(5)-Tic(7)-Tic(8))-bradykinin; NPC-16731; bradykinin, Arg(Hyp(3)-Thi(5)-Tic(7)-Tic(8))-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 16731: 1
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Bradykinin: 3860
NPC 16731: 1
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 16731: 1
Neuropeptides: 6772
Bradykinin: 3860
NPC 16731: 1
Oligopeptides: 519
Bradykinin: 3860
NPC 16731: 1
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Bradykinin: 3860
NPC 16731: 1
Inflammation Mediators: 1113
Autacoids: 276
Kinins: 2029
Bradykinin: 3860
NPC 16731: 1
Related Diseases
1.
Respiratory Hypersensitivity
11/01/1992 - "
5. Airway hyperresponsiveness and eosinophilia, induced by chronic antigen challenge, were markedly inhibited by the B2 antagonists, D-Arg-[Hyp3,D-Phe7]-BK (NPC 567) or D-Arg-[Hyp3,Thi5d-Tic7,Tic8]-BK (NPC 16731).NPC 16731 also abolished antigen-induced cyanosis, and delayed the onset of dyspnoea,doubling the time taken for animals to exhibit respiratory distress.6. The ability of BK receptor antagonists to inhibit antigen-induced airway hyperresponsiveness, in addition to eosinophilia, indicates an important role for endogenous kinins.
"
2.
Eosinophilia
11/01/1992 - "
5. Airway hyperresponsiveness and eosinophilia, induced by chronic antigen challenge, were markedly inhibited by the B2 antagonists, D-Arg-[Hyp3,D-Phe7]-BK (NPC 567) or D-Arg-[Hyp3,Thi5d-Tic7,Tic8]-BK (NPC 16731).NPC 16731 also abolished antigen-induced cyanosis, and delayed the onset of dyspnoea,doubling the time taken for animals to exhibit respiratory distress.6. The ability of BK receptor antagonists to inhibit antigen-induced airway hyperresponsiveness, in addition to eosinophilia, indicates an important role for endogenous kinins.
"
3.
Cyanosis
11/01/1992 - "
5. Airway hyperresponsiveness and eosinophilia, induced by chronic antigen challenge, were markedly inhibited by the B2 antagonists, D-Arg-[Hyp3,D-Phe7]-BK (NPC 567) or D-Arg-[Hyp3,Thi5d-Tic7,Tic8]-BK (NPC 16731).NPC 16731 also abolished antigen-induced cyanosis, and delayed the onset of dyspnoea,doubling the time taken for animals to exhibit respiratory distress.6. The ability of BK receptor antagonists to inhibit antigen-induced airway hyperresponsiveness, in addition to eosinophilia, indicates an important role for endogenous kinins.
"
Related Drugs and Biologics
1.
Kinins
2.
Antigens
3.
NPC 567