|1.||Huang, Leaf: 10 articles (05/2012 - 07/2007)|
|2.||Wei, Yu-Quan: 8 articles (08/2011 - 01/2008)|
|3.||Roth, Jack A: 7 articles (10/2013 - 03/2003)|
|4.||Ramesh, Rajagopal: 7 articles (01/2012 - 03/2003)|
|5.||Chen, Xiang: 6 articles (01/2012 - 05/2009)|
|6.||Wei, Yuquan: 5 articles (01/2015 - 05/2009)|
|7.||Wen, Yuan: 5 articles (01/2015 - 01/2010)|
|8.||Wang, Chun-Ting: 5 articles (01/2012 - 11/2009)|
|9.||Chen, Weihsu: 5 articles (05/2011 - 07/2007)|
|10.||Ito, Isao: 5 articles (12/2004 - 03/2003)|
05/01/2008 - "Overall, the improved DOTAP/E7-lipopeptide vaccine described herein showed a significantly enhanced therapeutic effect for the treatment of a cervical cancer model."
07/01/2015 - "Mean tumor volumes in Dotap-miR-155 compared with Dotap-scrambled were 322.80±120mm(3) and 76.00±39.3mm(3), P = .002 at day 24, respectively. "
01/01/2015 - "Tumor cells were transfected with murine FAP plasmids bearing the cationic lipid DOTAP. "
12/28/2013 - "The in vitro bioactivity profile of HoUrRu, as a pure compound or in formulation with POPC or DOTAP, reveals high antiproliferative activity against MCF-7 and WiDr human cancer cell lines."
07/06/2012 - "The results showed that PDLC was more potent than DOTAP or PIC to enhance vaccine-induced tumor-specific cytotoxic T lymphocyte (CTL) response and IFN-γ production. "
|2.||Cystic Fibrosis (Mucoviscidosis)
12/01/1996 - "Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP."
03/01/1997 - "Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis."
11/01/1995 - "Our results suggest that DOTAP merits testing in cystic fibrosis patients for delivery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene to the respiratory tract and that substitution of the cytomegalovirus (CMV) promoter for the simian virus (SV) promoter may improve on the transitory response reported previously."
11/01/1995 - "We have tested the cationic liposome N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethyl-ammoniummethylsul phate, (DOTAP), for gene delivery in vitro and in vivo with a view to clinical use in gene therapy for cystic fibrosis. "
09/01/1996 - "Transfection by DNA-DOTAP complexes at all ratios tested was unaffected by treatment of the complexes with DNase I. This finding has relevance to clinical trials for gene therapy of cystic fibrosis, in which patients are normally removed from treatment with DNase before receiving administration of DNA. "
|3.||Lung Neoplasms (Lung Cancer)
05/01/2009 - "Our experiments show that DOTAP is the most suitable transfection reagent for the delivery of 2'-O-methyl-RNA in human lung cancer cells according to its relatively low cytotoxicity and its ability to promote efficient uptake leading to the inhibition of telomerase."
01/01/2012 - "DOTAP:chol-TUSC2 can be safely administered intravenously in lung cancer patients and results in uptake of the gene by human primary and metastatic tumors, transgene and gene product expression, specific alterations in TUSC2-regulated pathways, and anti-tumor effects (to our knowledge for the first time for systemic DOTAP:cholesterol nanoparticle gene therapy). "
11/01/2000 - "We demonstrated the feasibility of the nlsLacZ gene-liposome (DOTAP) complex transfection in lung cancer cell lines H358 and Calu-1 carrying homozygous deletion of p53 and in primary cultures of human pleural metastatic tumor cells (n = 10). "
10/01/2013 - "Lewis lung cancer cell LL/2 transfected with the DOTAP:cholesterol cationic liposome could express the mouse IL-27 (mIL-27) gene at a relative high level. "
01/01/2013 - "This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung cancer (NSCLC). "
|4.||Neoplasm Metastasis (Metastasis)
04/01/2004 - "Furthermore, tumor cells treated with Ad-mda7 ex vivo or with DOTAP:Chol-mda7 complex in vivo formed significantly fewer tumors in an experimental lung metastasis model. "
11/01/2004 - "Furthermore, intravenous injections of DOTAP:Chol-FUS1 complex into mice bearing experimental A549 lung metastasis demonstrated significant (P = .001) decrease in the number of metastatic tumor nodules. "
01/01/2012 - "Administration of mSurvivinT34A plasmid complexed with cationic liposome (DOTAP/chol) resulted in the efficacious inhibition of tumor growth and lymph node metastasis within the mouse H22 tumor model. "
01/01/2008 - "Administration of Msurvivin T34A plasmid complexed with cationic liposome (DOTAP/Chol) resulted in significant inhibition in the growth and metastases of 4T1 tumor model. "
01/01/2008 - "The anti-tumor and anti-metastases activity of Msurvivin T34A plasmid complexed with cationic liposome (DOTAP/Chol) was evaluated in female BALB/c mice bearing 4T1 s.c. "
|5.||Wounds and Injuries (Trauma)
12/01/2005 - "For gene transfer in acute wounds, the administration of DOTAP/Chol liposomes appears to be beneficial."
12/01/2005 - "DOTAP/Chol liposomes improved epidermal regeneration by exhibiting the most rapid area and linear wound re-epithelization compared to DMRIE or control, P<0.001. "
12/01/2005 - "Rats were inflicted a full-excision acute wound and divided into three groups to receive weekly subcutaneous injections of DMRIE liposomes plus the Lac Z gene, or DOTAP/Chol liposomes plus the Lac Z gene, or saline. "
|4.||DNA (Deoxyribonucleic Acid)
|6.||Transferrin (beta 2 Transferrin)
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|8.||Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
|1.||Fluid Therapy (Oral Rehydration Therapy)
|5.||Heterologous Transplantation (Xenotransplantation)