Ro 24-7429

blocks the action of the HIV tat protein; an analog of Ro 5-3335; Proc Natl Acad Sci U S A 1993 Jul 15;90(14):6395-9

Also Known As:

7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine; Ro-24-7429

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Infections 11/01/1995 - "A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. " 09/01/1994 - "In acutely infected PBMCs Ro-5-3335 and Ro-24-7429 resulted in 68% and 68.5% mean inhibition at 10 microM; when the compounds were added 4 days after infection inhibition was less than 50% compared with controls. "
2.	Exanthema (Rash) 11/01/1995 - "The primary adverse effect of Ro 24-7429 was rash, which necessitated treatment discontinuation in 6 of 71 patients. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 03/01/1993 - "Theoretically, Ro 5-3335 and now its analogue Ro 24-7429 seem to possess all virtues to antagonize evolutive and latent AIDS. "
4.	Persistent Infection 07/15/1993 - "Importantly, Ro 24-7429 inhibited viral replication in both acute and chronic infection in vitro, a characteristic expected of a Tat antagonist and not shared by viral reverse transcriptase inhibitors. "

1.	Nucleosides
2.	Reverse Transcriptase Inhibitors
3.	Dihydrotachysterol (AT 10)
4.	Ro 5-3335