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2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxy

structure given in first source

Also Known As:

DMPO-OH

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Heterocyclic Oxides
  - Cyclic N-Oxides: 3
    - 2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxy: 15

Experts

1.	Ozawa, Toshihiko: 2 articles (04/2004 - 01/2003)
2.	Mizuno, Michiko: 1 article (04/2004)
3.	Nishizawa, Chiho: 1 article (04/2004)
4.	Suzuki, Kazuo T: 1 article (04/2004)
5.	Takeshita, Keizo: 1 article (04/2004)
6.	Ueda, Jun-ichi: 1 article (04/2004)
7.	Kato, Hiroharu: 1 article (01/2004)
8.	Kawai, Yoshiaki: 1 article (01/2004)
9.	Kubota, Eiro: 1 article (01/2004)
10.	Lee, Masaichi-Chang-Il: 1 article (01/2004)

Related Diseases

1.	Hypoxia (Hypoxemia) 09/30/1994 - "Upon reoxygenation after 60 min of anoxia, large DMPO-OH (aN = aH = 14.9 G) and smaller DMPO-R (aN = 15.8 G, aH = 22.8 G) signals were seen. " 06/01/1993 - "Both DMPO-OH adduct generation and chemiluminescence emission were considerably increased after one to three hours of reoxygenation, although they increased only slightly after 45 minutes of hypoxia. " 06/01/1998 - "This finding strongly suggests an increased rate of DMPO-OH formation which originally derived from enhanced superoxide anion radical production due to hypoxia/reoxygenation. " 03/01/1994 - "On reoxygenation with addition of a 50 mM concentration of the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), after 90 min of anoxia an electron paramagnetic resonance (EPR) signal was observed consisting of 2 components: a quartet 1:2:2:1 DMPO-OH signal, aN = aH = 14.9 G, and a six-peaked DMPO-R signal, aN = 15.6 G aH = 22.9 G, whereas cells in air gave no signal. "
2.	Photosensitivity Disorders (Photodermatitis) 08/25/1995 - "Upon photosensitization of HY in the presence of mitochondrial membranes, the electron spin resonance (ESR) signal of 2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxyl (DMPO/.OH) was increased by a mechanism which was suppressed by DSF. " 12/01/1983 - "EPR spin trapping experiments show that photoexcited FCD produce hydroxyl radicals as detected by the formation of a DMPO-OH signal which can be abolished when the photosensitization reaction is carried out in the presence of specific OH scavengers. " 04/01/2004 - "The ESR signal of the hydroxyl radical (OH) adduct of DMPO (DMPO-OH) resulting from 1O2-dependent generation of OH strengthened remarkably in the presence of reduced glutathione (GSH), 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), ascorbic acid, NADPH, etc. A similar increase was observed in the photosensitization of uroporphyrin (UP), rose bengal (RB) or methylene blue (MB). "
3.	Pancreatitis 02/01/1990 - "By the spin-trapping method (DMPO) at 25 degrees C, DMPO-OH adduct and 3-Line and 6-Line were detected in CDE diet-induced acute pancreatitis. " 09/01/1989 - "coli in the model of endotoxemia, and 3- and 6-lines and a signal suggestive of DMPO-OH adduct were noted at 12 and 24 h in ethionine pancreatitis. "
4.	Ischemia 01/01/1994 - "In accordance with the duration of ischemia, the concentrations of DMPO-OOH and DMPO-OH were highest after 60 min of ischemia, and then after 30, 90, and 10 min of ischemia in decreasing order. " 01/01/1991 - "The addition of iron further stimulated this change eliciting a Fenton-type reaction responsible for DMPO-OH.-related ESR spectra in the perfusate after ischemia. "
5.	Endotoxemia 09/01/1989 - "coli in the model of endotoxemia, and 3- and 6-lines and a signal suggestive of DMPO-OH adduct were noted at 12 and 24 h in ethionine pancreatitis. "

Related Drugs and Biologics

1.	5,5-dimethyl-1-pyrroline-1-oxide
2.	Hydroxyl Radical
3.	Suspensions
4.	Iron
5.	hydroxide ion
6.	Superoxides (Superoxide)
7.	Rose Bengal
8.	NADP (NADPH)
9.	Methylene Blue (Methylthioninium Chloride)
10.	Glutathione (Reduced Glutathione)