leuhistin

aminopeptidases N inhibitor from Bacillus laterosporus BMI156-14F1; structure given in second source

Also Known As:

3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhexanoic acid; 1H-Imidazole-4-propanoic acid, alpha-(1-amino-3-methylbutyl)-alpha-hydroxy-, (R-(R*,S*))-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - leuhistin: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - leuhistin: 2

Related Diseases

1.	Inflammation (Inflammations) 01/01/1998 - "Repeated intravenous administration (6 times) of spinorphin every hour significantly suppressed carrageenan-induced polymorphonuclear neutrophil (PMN) accumulation, an indicator of inflammation (3.21+/-0.95 x 10[6] cells vs 8.92+/-0.96 x 10[6] cells, 10mg/kg spinorphin-treated vs saline-treated group, n=5, P<0.01) at 6 hr. The combination of spinorphin and leuhistin (2 mg/kg, i.v.), a specific inhibitor of aminopeptidase N (APN), markedly suppressed the PMN accumulation induced by carrageenan (1.11+/-0.17 x 10[6] cells, 88% inhibition compared to the saline-treated group, n=5, P<0.01). "
2.	Fibrosarcoma 01/01/1996 - "The aminopeptidase expressed by the human metastatic HT1080 fibrosarcoma cells was effectively suppressed by actinonin A, bestatin, leuhistin and matlystatin A, which are capable of inhibiting the purified aminopeptidase N, but not by arphamenine B specific for aminopeptidase B. "

Related Drugs and Biologics

1.	CD13 Antigens (Alanine Aminopeptidase)
2.	Indicators and Reagents (Reagents)
3.	Carrageenan
4.	Aminopeptidases
5.	spinorphin
6.	matlystatin A
7.	arphamenine B
8.	aminopeptidase B
9.	ubenimex
10.	actinonin

Related Therapies and Procedures

1.	Intravenous Administration