progelatinase

MW 72 kDa; tissue inhibitor of metalloproteinase-2 binds to stabilization site, thereby preventing autocatalytic activation & degradation but not gelatinolysis by the enzyme-inhibitor complex

Also Known As:

gelatinase precursor; pro-MMP-2; proMMP-2; progelatinase A; progelatinase B

Networked: 295 relevant articles (4 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        Gelatinases: 1359
        progelatinase: 295
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        Gelatinases: 1359
        progelatinase: 295
- Enzyme Precursors: 724
  - progelatinase: 295
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protein Precursors: 37
    - Enzyme Precursors: 724
      - progelatinase: 295

Experts

1.	Annabi, Borhane: 6 articles (01/2018 - 01/2002)
2.	Cao, Jian: 5 articles (07/2015 - 12/2002)
3.	Opdenakker, Ghislain: 4 articles (08/2014 - 12/2004)
4.	Chatterjee, Amitava: 4 articles (03/2010 - 01/2005)
5.	Béliveau, R: 4 articles (10/2001 - 03/2000)
6.	Gingras, D: 4 articles (10/2001 - 03/2000)
7.	Sato, H: 4 articles (09/2001 - 01/2000)
8.	Seiki, M: 4 articles (09/2001 - 01/2000)
9.	Okada, Y: 4 articles (03/2001 - 01/2000)
10.	Discher, Philipp: 3 articles (01/2020 - 01/2016)

Related Diseases

1.	Glioma (Gliomas) 03/01/2012 - "Moreover, mutant IDH2-induced HIF-1α improved the secretion levels of pro-MMP-2 and pro-MMP-9 as well as the conversion from pro-MMP-2 to its active form, giving C6 glioma cells a higher migration potential. " 05/15/2003 - "However, after coculture with the U251N glioma line, astrocyte pro-MMP-2 was converted to the active form. " 07/28/2009 - "Microglial MT1-MMP in turn activates glioma-derived pro-MMP-2 and promotes glioma expansion, as shown in an ex vivo model using MT1-MMP-deficient brain tissue and a microglia depletion paradigm. " 01/01/2000 - "SDS-PAGE zymography and Western blotting revealed that the expression of proMMP-2 in rat brains with C6 glioma cells was significantly higher than that in normal or the sham-operated rat brains, and that the activated form of MMP-2 was detected only in the former but not in the latter. " 04/01/2007 - "Cytoskeleton-disrupting agents such as concanavalin A (ConA) and cytochalasin D triggered proMMP-2 activation and cell death in U87 glioma cells. "
2.	Lymphoma (Lymphomas) 01/01/2008 - "Plasma levels of proMMP-2 and MMP-2-TIMP-2 complex as well as the proMMP-2/TIMP-2 ratio were significantly higher in patients with active lymphoma and those in remission when compared to healthy controls. " 01/01/2008 - "Moreover, plasma levels of MMP-2-TIMP-2 complex, proMMP-2, TIMP-2, and proMMP-2/TIMP-2 ratio are at abnormal level in patients with newly diagnosed lymphoma and those in remission when compared to healthy controls. "
3.	Lung Diseases (Lung Disease) 07/02/2004 - "These results suggest that PDE4 inhibitors are effective in inhibiting the pro-MMP-2 and pro-MMP-1 secretion induced by TNF-alpha and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling."
4.	Emphysema 10/01/2011 - "Pro-MMP-2, MMP-2, and MMP-9 activity did not correlate with the protective effects of AOD on cigarette smoke-induced emphysema. "
5.	Neoplasms (Cancer) 04/01/2007 - "In this study, we demonstrate that MSeA suppresses pro-MMP-2 activation in a dose-dependent manner induced by 12-O-tetradecanoylphorbol-13-acetate (PMA), and further decreases the invasiveness of HT1080 tumor cells. " 09/01/2005 - "In the present study, we evaluated the effect of NaBu on pro-MMP-9 and pro-MMP-2 secretion in human Jurkat and HT1080 cells, and in 36 pediatric solid tumors. " 10/01/2023 - "Dogs with benign and malignant mammary tumors showed bands of pro-MMP-2, pro-MMP-9 and active MMP-9. " 01/01/2022 - "Moreover, the availability of the established ECM mimic is able to distinguish active MMP-2 from latent proMMP-2 in tumor samples. " 07/01/2015 - "In support of a critical relationship between these two genes, miR-181a-5p-mediated reduction of MMP-14 levels was sufficient to decrease cancer cell migration, invasion, and activation of pro-MMP-2. "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-2
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Phosphodiesterase 4 Inhibitors
4.	Smoke
5.	Matrix Metalloproteinases (MMPs)
6.	Matrix Metalloproteinase 14 (MT1-MMP)
7.	Metalloproteases (Metalloproteinases)
8.	pro-matrix metalloproteinase 9
9.	Matrix Metalloproteinase 2 (Gelatinase A)
10.	Tissue Inhibitor of Metalloproteinases

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)