necdin

03/01/2006 - "These data suggest that changes in necdin and E2F4 expression after rosiglitazone exposure in humans are associated with altered adipocyte differentiation and may contribute to improved insulin sensitivity in humans treated with TZDs."
01/01/2013 - "The insulin-like growth factor-1 (IGF-1) signaling pathway promotes adipocyte differentiation and, therefore, insulin sensitivity by suppression of necdin expression, which represses peroxisome proliferator-activated receptor-gamma promoter activity by interaction with E2F4 in mouse adipocytes. "

01/01/2021 - "In previous studies, we showed that cystin regulates Myc expression via interaction with the tumor suppressor, necdin. "
05/01/2009 - "These studies suggest a role for Necdin in the regulation of downstream cellular targets in a hypoxic environment in virus-associated human cancers."
01/01/2016 - "Apart from the classical role as tumor suppressor, p53 during steady state hematopoiesis is associated with the maintenance of quiescent cell population in bone marrow by upregulating necdin (Ndn) and Gfi-1. "
04/02/2013 - "Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer."
01/01/2012 - "The proposed tumor suppressor Necdin, known to be regulated by p53, was within a group of genes that was consistently upregulated in the presence of PyLT. "

01/01/2020 - "In this study, we demonstrate that necdin, one of the Prader-Willi syndrome (PWS)-causative genes, is highly expressed in the suprachiasmatic nuclei (SCN), the pacemaker of circadian clocks in mammals. "
01/01/2020 - "Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader-Willi syndrome."
10/31/2017 - "Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome."
04/10/2012 - "Necdin is one of several genes inactivated in children with Prader-Willi syndrome, who are predisposed to increased adiposity at the expense of lean mass. "
04/01/2011 - "Necdin deletion is associated with Prader-Willi syndrome. "

03/14/2016 - "Forced expression of necdin enhances mitochondrial function in primary cortical neurons and human SH-SY5Y neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration. "
01/16/2004 - "Overexpression of p75 translocated necdin and MAGE-G1 in the proximity of the plasma membrane and reduced their association with E2F1 to facilitate E2F1-induced death of neuroblastoma cells. "
11/01/2002 - "Necdin was undetectable in mouse neuroblastoma N1E-115 cells under undifferentiated and differentiated conditions. "
11/01/2002 - "Here we demonstrate that ectopic expression of necdin induces a neuronal phenotype in neuroblastoma cells. "
11/01/2002 - "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells."

10/13/2015 - "Earlier studies using a mammary tumorigenesis mouse model identified Necdin (Ndn)as a germline modifier of metastasis. "