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butixocort 21-propionate
structure given in first source
Also Known As:
JO 1222; JO-1222; Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-((1-oxopropyl)thio)-, (11beta)-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Pregnanes: 9
Pregnenes: 1
Pregnenediones
butixocort 21-propionate: 1
Related Diseases
1.
Rhinitis
01/01/1991 - "
These findings suggest that JO 1222 is a novel, potent, locally acting corticosteroid with little or no systemic effects and thus has therapeutical potential in diseases such as asthma, arthritis, ulcerative colitis and rhinitis.
"
2.
Pleurisy (Pleuritis)
01/01/1991 - "
In models of acute inflammation, JO 1222 had an ED30 of 3 micrograms in carrageenan-induced oedema, an ED50 of 5 ng in croton oil-induced inflammation, and 4 micrograms and 2 micrograms/pleural cavity in carrageenin-induced pleurisy in the rat and mouse respectively.
"
3.
Inflammation (Inflammations)
01/01/1991 - "
In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity.
"
01/01/1991 - "
In models of acute inflammation, JO 1222 had an ED30 of 3 micrograms in carrageenan-induced oedema, an ED50 of 5 ng in croton oil-induced inflammation, and 4 micrograms and 2 micrograms/pleural cavity in carrageenin-induced pleurisy in the rat and mouse respectively.
"
01/01/1991 - "
Tixocortol 17-butyrate,21-propionate (JO 1222) is a novel, locally acting, C-21 thioester-linked corticosteroid with significant activity in a number of models of inflammation.
"
4.
Hypersensitivity (Allergy)
01/01/1991 - "
In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity.
"
5.
Granuloma
01/01/1991 - "
In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity.
"
Related Drugs and Biologics
1.
Oxazolone
2.
Croton Oil
3.
Carrageenan
4.
Beclomethasone (Beclometasone)
5.
Adrenal Cortex Hormones (Corticosteroids)
6.
tixocortol
7.
compound 21