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sialosyl dimeric Le(x) antigen

structure given in first source
Also Known As:
FH-4 antigen; di-Le(x); difucosyl lactosamine; dimeric Le(x); sialyl diLe(x); sialyl dimeric Le(x) antigen
Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Asnani, Ari: 1 article (10/2010)
2. Auzanneau, France-Isabelle: 1 article (10/2010)
3. Wang, Jo-Wen: 1 article (10/2010)
4. Hakomori, S: 1 article (07/2000)

Related Diseases

1. Neoplasms (Cancer)
07/01/1989 - "For example, some areas of a given tumor were stained by FH4 (defining dimeric Le(x)), while other complementary areas were strongly stained, in a mutually exclusive manner, by SH1 (defining Le(x)), AH6 (defining Le(y)), FH6 (defining sialosyl dimeric (Le(x)), or TKH2 (defining sialosyl-Tn). "
07/01/2000 - "Various novel types of GSLs such as extended globo-series, sialyl-Le(x) (SLe(x)), sialyl-dimeric-Le(x) (SLe(x)-Le(x)), dimeric-Le(x) (Le(x)-Le(x)), Le(y)-on-Le(x), dimeric-Le(a) (Le(a)-Le(a)), Le(b)-on-Le(a), etc. were identified as tumor-associated antigens. "
07/01/1989 - "Comparisons of the mosaic-staining patterns with cytohistological properties of tumor cells within specific areas suggested that the pattern of antigen expression is correlated with degree of differentiation; e.g., poorly-differentiated cells with severe dysplasia did not express high levels of Le(x) or Le(y) but did express sialyl-Le(x) or dimeric Le(x); on the other hand, moderately or well-differentiated tumor cells in some areas expressed high levels of Le(x) or Le(y) but lower levels of sialyl-Le(x). "
05/01/1991 - "Immunochemical studies of human colorectal carcinoma with various monoclonal antibodies against Le(X)-related carbohydrate antigens previously revealed that the amount of sialyl-dimeric Le(X) antigen (NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-R: SLX) associated with metastatic lesions was greater than in the primary tumors. "
05/01/1991 - "Various carbohydrate epitopes expressed at the cell surface were analysed by cytofluorometry using various monoclonal antibodies (MAbs) directed to Le(x), sialosyl-Le(x), sialosyl dimeric Le(x), T, Tn and sialosyl-Tn structures, which are often reported as being highly expressed in a variety of human cancers, particularly adenocarcinoma. "
2. Colorectal Neoplasms (Colorectal Cancer)
3. Melanoma (Melanoma, Malignant)
4. Transitional Cell Carcinoma
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Antigens
2. Monoclonal Antibodies
3. 5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)
4. E-Selectin
5. P-Selectin
6. Epitopes
7. First Step
8. A-trisaccharide
9. sialyl Le(a) ganglioside

Related Therapies and Procedures

1. Intradermal Injections