|1.||Todeschini, Adriane R: 7 articles (01/2014 - 05/2002)|
|2.||Campetella, Oscar: 6 articles (06/2014 - 03/2002)|
|3.||Tarleton, Rick L: 6 articles (07/2010 - 06/2003)|
|4.||Roitberg, Adrian E: 5 articles (10/2013 - 04/2009)|
|5.||Rodrigues, Mauricio M: 5 articles (09/2009 - 09/2003)|
|6.||Mucci, Juan: 4 articles (06/2014 - 03/2002)|
|7.||Bruna-Romero, Oscar: 4 articles (01/2014 - 09/2006)|
|8.||Freire-de-Lima, Leonardo: 4 articles (01/2012 - 01/2008)|
|9.||Gazzinelli, Ricardo T: 4 articles (09/2009 - 09/2004)|
|10.||Claser, Carla: 4 articles (09/2009 - 09/2004)|
|1.||Chagas Disease (American Trypanosomiasis)
10/01/2013 - "Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis)."
10/01/2012 - "T rypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas' disease."
04/21/2009 - "trans-Sialidase is an essential enzyme for Trypanosoma cruzi, the causative agent of Chagas' disease, to escape from the host immune system and to invade the host cells. "
02/01/2009 - "trans-Sialidase from Trypanosoma cruzi (TcTS) has emerged as a potential drug target for treatment of Chagas disease. "
02/01/2008 - "cruzi trans-sialidase to serve as a potential drug target against Chagas disease. "
06/01/2014 - "Taking together these results reveal roles of TcRab11 in osmoregulation and trafficking of trans-sialidase to the plasma membrane, the role of trans-sialidase in promoting infection, and a novel unconventional mechanism of GPI-anchored protein secretion. "
08/01/2013 - "cruzi infection by trans-sialidase (TS) inhibition assay (TIA). "
08/01/2013 - "Trans-sialidase inhibition assay detects Trypanosoma cruzi infection in different wild mammal species."
01/01/2013 - "In a murine model of experimental Trypanosoma cruzi (H8 strain) infection, we investigated the induction of protective immunity against the domains [amino (A), repeats (R) and carboxyl (C)] of the surface protein (SP), a member of the trans-sialidase (TS) superfamily. "
04/01/2011 - "In vivo infection by Trypanosoma cruzi: the conserved FLY domain of the gp85/trans-sialidase family potentiates host infection."
01/01/2005 - "Consistent with this, parasite strains known to exhibit more trans-sialidase activity induced heavier thrombocytopenia. "
01/01/2013 - "These effects are partially promoted by the parasite trans-sialidase (TS), which is shed in the blood and depletes sialic acid from the platelets, inducing accelerated platelet clearance and causing thrombocytopenia during the acute phase of disease. "
01/01/2005 - "Results reported here strongly support the hypothesis that the trans-sialidase is the virulence factor that, after depleting the sialic acid content of platelets, induces the accelerated clearance of the platelets that leads to the thrombocytopenia observed during acute Chagas' disease."
01/01/2005 - "The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents."
01/01/2004 - "The present paper proposes a new therapy using Trypanosoma cruzi trans-sialidase to treat diseases with unclear pathogenesis that present in common chronic inflammation and fibrosis. "
07/01/2009 - "Finally, we will review the results of molecular studies suggesting that parasite-induced inflammation and tissue damage is, at least in part, mediated by the activities of trans-sialidase, mucin-linked lipid anchors (TLR2 ligand) and cruzipain (a kinin-releasing cysteine protease). "
08/01/2007 - "cruzi trans-sialidase protein or adoptive transfer of trans-sialidase-specific T-cell clones decreased parasitemia, morbidity, and mortality. "
05/01/1995 - "A single dose of either endogenous or recombinant trans-sialidase injected into the connective tissues of BALB/c mice greatly enhanced parasitemia and mortality. "
03/01/2001 - "During infections, an antibody response against the catalytic region of the trans-sialidase that is coincident with the control of the parasitemia and survival of the host is observed. "
|1.||N-Acetylneuraminic Acid (Sialic Acid)
|5.||DNA (Deoxyribonucleic Acid)
|7.||Cysteine Proteases (Cysteine Protease)
|8.||Membrane Proteins (Integral Membrane Proteins)
|2.||Drug Therapy (Chemotherapy)