magnosalin

from crude Japanese drug Shin-i; inhibits adjuvant-induced angiogenesis & granuloma formation in the mouse pouch; structure given in first source; RN given refers to cpd without isomeric designation

Also Known As:

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kimura, Ikuko: 1 article (02/2002)
2.	Kiniwa, Mamoru: 1 article (02/2002)
3.	Konno, Yasuo: 1 article (02/2002)
4.	Kuraishi, Yasushi: 1 article (02/2002)
5.	Suzuki, Takashi: 1 article (02/2002)
6.	Tanaka, Katsunao: 1 article (02/2002)

Related Diseases

1.	Osteoarthritis 05/01/1998 - "The effects of magnosalin for FBS-induced thymidine incorporation into the cells of the CIA mice and the RA patients were significantly greater than those in the corresponding control mice and osteoarthritis patients. "
2.	Rheumatoid Arthritis 02/25/2002 - "This magnosalin derivative with anti-angiogenic effects is a candidate for the treatment of rheumatoid arthritis." 05/01/1998 - "This study was undertaken to examine the effects of magnosalin, a compound isolated from 'Shin-i' (Flos magnoliae) on proliferation of synovial cells isolated from MRL/1pr and collagen-induced arthritis (CIA) mice, and rheumatoid arthritis (RA) patients. " 05/01/1998 - "Inhibitory effects of anti-rheumatic drugs containing magnosalin, a compound from 'Shin-i' (Flos magnoliae), on the proliferation of synovial cells in rheumatoid arthritis models."
3.	Experimental Arthritis 05/01/1998 - "This study was undertaken to examine the effects of magnosalin, a compound isolated from 'Shin-i' (Flos magnoliae) on proliferation of synovial cells isolated from MRL/1pr and collagen-induced arthritis (CIA) mice, and rheumatoid arthritis (RA) patients. " 02/25/2002 - "TAS-202 inhibited the proliferation of vascular endothelial cells more potently than magnosalin, and when given orally it inhibited basic fibroblast growth factor (bFGF)-induced angiogenesis and collagen-induced arthritis in mice. "
4.	Granuloma 01/01/1990 - "Magnosalin inhibited angiogenesis 2.4-fold (intra-pouch) and 9.7-fold (intraperitoneal) more strongly than granuloma formation. " 01/01/1991 - "The anti-chronic inflammatory effect of "shin-i" was caused by selective inhibition of angiogenesis by magnosalin and of granuloma formation by magnoshinin." 01/01/1991 - "Selective inhibition by magnosalin and magnoshinin, compounds from "Shin-i" (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch." 01/01/1990 - "These results show that the anti-chronic inflammatory effect of 'Shin-i' was caused by selective inhibition of angiogenesis by magnosalin and of granuloma formation by magnoshinin." 01/01/1990 - "Selective inhibition by magnosalin and magnoshinin, compounds from 'shin-i' (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch."

Related Drugs and Biologics

1.	Thymidine
2.	magnoshinin
3.	Croton Oil
4.	Antirheumatic Agents (DMARD)
5.	Lignans
6.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
7.	Oils
8.	Hydrocortisone (Cortisol)
9.	Essential Fatty Acids
10.	Alkaloids