BE 10988

from a strain of actinomycetes; structure given in first source

Also Known As:

BE-10988; 4-Thiazolecarboxamide, 2-(5-amino-4,7-dihydro-1-methyl-4,7-dioxo-1H-indol-3-yl)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Eisenreich, Wolfgang: 1 article (07/2008)
2.	Glawischnig, Erich: 1 article (07/2008)
3.	Rauhut, Thomas: 1 article (07/2008)
4.	Spiteller, Michael: 1 article (07/2008)
5.	Spiteller, Peter: 1 article (07/2008)

1.	Neoplasms (Cancer) 07/18/2008 - "The biosynthetic origin of the tumor-inhibitory derivative, BE-10988, was studied in Streptomyces sp . "
2.	Leukemia 05/01/1991 - "BE-10988 increased DNA-topoisomerase complex formation and inhibited the growth of both doxorubicin-resistant and vincristine-resistant P388 murine leukemia cell lines, as well as sensitive P388 cell lines."

1.	Vincristine (Oncovin)
2.	Doxorubicin (Adriamycin)
3.	Type I DNA Topoisomerases (Topoisomerase I)