|1.||Liu, Cheng: 7 articles (07/2015 - 06/2003)|
|2.||Xiang, Rong: 7 articles (01/2013 - 01/2006)|
|3.||Reisfeld, Ralph A: 6 articles (01/2013 - 08/2006)|
|4.||Liu, Yuan: 5 articles (07/2015 - 01/2006)|
|5.||Luo, Yunping: 5 articles (12/2011 - 01/2006)|
|6.||Ohkubo, Iwao: 4 articles (11/2015 - 04/2007)|
|7.||Yamane, Takuya: 4 articles (11/2015 - 04/2007)|
|8.||Solberg, Rigmor: 4 articles (07/2014 - 01/2010)|
|9.||Yamamoto, Yoshio: 3 articles (11/2015 - 04/2007)|
|10.||Ariga, Hiroyoshi: 3 articles (11/2015 - 01/2013)|
10/01/2015 - "Our study presents a novel prodrug, CBZ-AAN-Dox, to potentially increase both the safety and efficacy of clinical treatment of tumors by exploiting the tumor's innate expression of legumain. "
01/01/2015 - "We included case-controlled studies of legumain and cancer. "
01/01/2013 - "In our study, legumain-targeting liposomal nanoparticles (NPs) encapsulating HC were employed to suppress STAT3 activity and "re-educate" TAMs, and to investigate the effects of suppression of tumor progression in vivo. "
01/01/2012 - "The crystallization and preliminary diffraction data analysis of active legumain are presented, which form an important basis for further studies that should clarify fundamental aspects of activation, activity and inactivation of legumain, which is a key target in (auto-)immunity and cancer."
02/19/2010 - "Legumain is also up-regulated in a number of human cancers, and recent studies suggest that it may play important functional roles in the process of tumorigenesis. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2014 - "Legumain might be a new potential biomarker for breast cancer, which may reflect the prognosis and overall survival."
01/01/2014 - "Multivariate survival analysis suggested that the positive legumain expression was an independent predictor of poorer overall survival in patients with breast cancer (HR=0.24; 95%CI 0.11-0.65, p=0.03). "
01/01/2014 - "Positive legumain expression was significantly associated with shorter overall survival time in breast cancer patients (log-rank p<0.01). "
01/01/2014 - "The results indicated that positive expression of legumain protein in breast cancer was 51.8 % (59/114) and the positive expression of legumain protein in adjacent non-cancerous tissue was 11.5% (3/26). "
03/01/2007 - "Besides being of prognostic value, legumain might prove to be an important predictive factor in breast cancer, since its unique cleavage specificity is already used in prodrug activation strategies."
|3.||Stomach Neoplasms (Stomach Cancer)
01/01/2013 - "In this study, a tissue microarray (TMA) containing 282 samples of primary gastric cancer was assessed for Legumain expression by immunohistochemistry. "
01/01/2013 - "In this study, we investigated effects of legumain on gastric cancer and the correlation between legumain expression and prognosis of gastric cancer patients. "
01/01/2013 - "Cytoplasmic immunoreactivity of Legumain was over-expressed in gastric cancer compared with paired normal gastric mucosa. "
01/01/2013 - "Legumain was highly expressed in gastric cancer patients and some gastric cancer cell lines. "
01/01/2013 - "Tissue microarray analysis from 112 gastric cancer patients was performed to evaluate the association between legumain expression and the cumulative survival time. "
|4.||Neoplasm Metastasis (Metastasis)
01/01/2013 - "Increased Legumain levels were significantly correlated with clinical stage, presence of distant metastasis. "
01/01/2015 - "In colon cancer patients, high legumain expression was associated with overall and metastasis-free survival (OS; MFS) in uni- and multivariate analysis. "
01/01/2013 - "Legumain expression could serve as a prognostic biomarker in patients at risk of developing metastasis or recurrence with gastric carcinoma."
01/01/2013 - "Legumain was significantly over-expressed in primary gastric cancer with metastasis than without metastasis. "
01/01/2013 - "Expression of legumain correlates with prognosis and metastasis in gastric carcinoma."
|5.||Colorectal Neoplasms (Colorectal Cancer)
03/15/2005 - "However, there is no study examining the relationship of legumain expression to clinocopathologic and biological variables in colorectal cancers. "
01/01/2015 - "Expression of legumain was examined in a panel of 277 primary tumours from colorectal cancer (CRC) patients using immunohistochemistry. "
07/01/2014 - "The prodrug was more toxic to the colorectal cancer HCT116 cells (expressing both the 36kDa active and 56kDa proform of legumain) than SW620 cells (only expressing the 56kDa prolegumain) indicating a relationship between toxicity of the prodrug and activity of legumain in the cells. "
01/01/2013 - "In the present work, legumain expression was examined in colorectal cancer cell lines. "
01/01/2013 - "Nuclear legumain activity in colorectal cancer."
|1.||DNA (Deoxyribonucleic Acid)
|2.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|3.||Transforming Growth Factor beta (TGF-beta)
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|6.||glucuronyl glucosamine glycan sulfate (Vessel)
|7.||Cysteine Proteases (Cysteine Protease)
|2.||Heterologous Transplantation (Xenotransplantation)
|3.||Prostatectomy (Retropubic Prostatectomy)