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panadiplon
structure given in first source; RN from Toxlit
Also Known As:
3-(5-cyclopropyl-1,2,4-oxadiazol 3-yl)-5-(1-methylethyl)imidazo(1,5-a)quinoxalin-4(5H)-one; U 78875; U-78875
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Oxazoles: 89
Oxadiazoles: 146
panadiplon: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinoxalines: 324
panadiplon: 4
Related Diseases
1.
Anterograde Amnesia
10/01/1991 - "
In the mouse one-trial passive avoidance task, pretreatment with U-78875 (1-10 mg/kg) before training produced no anterograde amnesia, but completely blocked the amnesic effect from diazepam (10 mg/kg).
"
2.
Mitochondrial Diseases (Mitochondrial Disease)
11/02/1998 - "
Our results indicate that panadiplon induces a mitochondrial dysfunction in the liver, and suggest that this dysfunction may be attributed to the carboxylic acid metabolite.
"
3.
Necrosis
04/15/1996 - "
The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular steatosis and centrilobular necrosis in rabbits.
"
4.
Hypothermia
05/12/1993 - "
Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice.
"
5.
Hypoxia (Hypoxemia)
04/15/1996 - "
Both cotreatments reduced the level of LDH leakage produced by panadiplon during hypoxia.
"
04/15/1996 - "
Cells treated with panadiplon, then exposed to hypoxia conditions, showed a significant level of injury compared to normoxic control cultures, and a further reduction in ATP.
"
04/15/1996 - "
Cotreatment did not generally increase ATP or glycogen levels (compared to panadiplon treatment groups) during hypoxia, though individual experiments showed a slight increase in ATP levels.
"
Related Drugs and Biologics
1.
Diazepam (Valium)
2.
Anti-Anxiety Agents (Anxiolytics)
3.
Glycogen
4.
Carboxylic Acids
5.
Benzodiazepines
6.
Adenosine Triphosphate (ATP)