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alpha-methylhistamine

a histamine H3 receptor agonist; RN given refers to parent cpd without isomeric designation
Also Known As:
alpha-methylhistamine dihydrochloride; alpha-methylhistamine, (R)-isomer; alpha-methylhistamine, (S)-isomer
Networked: 34 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Pillai, K K: 2 articles (08/2010 - 08/2006)
2. Vohora, Divya: 2 articles (08/2010 - 08/2006)
3. Zou, Zui: 1 article (09/2014)
4. Raya, Abou Dargham: 1 article (09/2014)
5. Tian, Mou-Li: 1 article (09/2014)
6. Shi, Xue-Yin: 1 article (09/2014)
7. Zhang, Hao: 1 article (09/2014)
8. Li, Wei-Wei: 1 article (09/2014)
9. Wang, Yun: 1 article (09/2014)
10. Cheng, Long-Zhen: 1 article (09/2014)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Mydriasis
3. Gastric Fistula
08/01/1994 - "The involvement of histamine H3 receptors in the regulation of gastric acid secretion was investigated in the conscious dog with gastric fistula, by the use of the selective agonist (R)alpha-methylhistamine and the selective antagonist thioperamide. "
01/01/1993 - "The effect of (R)alpha-methylhistamine (MH) and thioperamide (selective agonist and antagonist respectively of histamine H3 receptors) was examined in conscious gastric fistula dogs to investigate the role of histamine H3 receptors in the control of basal and stimulated gastric acid secretion. "
02/01/1991 - "In an attempt to assess the role of histamine H3 receptors in the control of gastric acid secretion, the effects of the selective histamine H3 receptor agonist, (R) alpha-methylhistamine and antagonist, thioperamide were evaluated in the conscious gastric fistula cat under basal conditions and against different stimuli. "
12/01/1999 - "After intragastric administration of BP 2-94 (10 mg/kg), both the prodrug and (R)-alpha-methylhistamine were detected in plasma: plasma levels of (R)-alpha-methylhistamine decayed with a T1/2 of about 1 hr and displayed concentrations as high as 50-fold the EC50 of the drug at the H3 receptor for at least 2 hr. In conscious dogs provided with gastric fistula BP 2-94, administered at 10 and 30 mg/kg intragastrically, caused a dose-dependent inhibition (maximum reduction was about 80%) of the acid secretion stimulated by 2-deoxy-D-glucose, whereas (R)-alpha-methylhistamine (20 mg/kg, intragastrically) was ineffective. "
4. Seizures (Seizure)
5. Tachycardia (Tachyarrhythmias)

Related Drugs and Biologics

1. Histamine H3 Receptors (Histamine H3 Receptor)
2. BP 2-94
3. thioperamide
4. Histamine (Histamine Dihydrochloride)
5. Histamine Agonists
6. Ranitidine (Zantac)
7. Cetirizine (Zyrtec)
8. Pyrilamine (Mepyramine)
9. Cimetidine (Biomet)
10. Pertussis Toxin

Related Therapies and Procedures

1. Aftercare (After-Treatment)