fascaplysine

12/24/2017 - "Similarly, fascaplysin was observed to have improved anti-cancer effects in combination with compound C, a selective AMPK inhibitor. "
07/17/2011 - "Previous studies indicated that fascaplysin derived from marine sponge can induce tumor cell death by apoptosis and possesses anti-angiogenesis activity. "
12/24/2017 - "Fascaplysin, a natural product isolated from marine sponges, is a potential candidate for the development of anti-cancer drugs. "
12/24/2017 - "Fascaplysin Sensitizes Anti-Cancer Effects of Drugs Targeting AKT and AMPK."
09/29/2017 - "Fascaplysin, therefore, represents a potential therapeutic approach for the treatment of multiple types of solid cancer."

03/07/2014 - "In this study, cytotoxic activity of fascaplysin against a panel of small cell lung cancer (SCLC) cell lines and putative synergism with chemotherapeutics was investigated. "
03/07/2014 - "Cytotoxic effects of fascaplysin against small cell lung cancer cell lines."
10/14/2018 - "Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines."
10/14/2018 - "The cytotoxic activity of fascaplysin was studied using lung cancer cell lines, primary Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) cells, as well as SCLC circulating tumor cell lines (CTCs). "

01/01/1991 - "No significant antitumor effect of fascaplisine was stated when its in vivo antitumor activity was studied with doses of 5 to 20 mg/kg on a model of Ehrlich ascitic carcinoma. "
11/30/2017 - "The present study investigated the anti-tumor effects of a highly selective CDK4 inhibitor fascaplysin in ovarian carcinoma cell lines. "
11/30/2017 - "Above all, our results showed that fascaplysin has anti-tumor activity against ovarian cancer cell lines through inhibiting CDK4, and may be a therapeutic target for the treatment of ovarian carcinomas."

11/30/2017 - "In our study, cell proliferation, cell cycle, cell apoptosis, cell invasion, and cell migration relative assays were performed in ovarian cancer cell lines A2780 and OVCAR3 in the presence of different concentrations of fascaplysin. "
11/30/2017 - "Our results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. "
11/30/2017 - "Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4."
11/30/2017 - "Above all, our results showed that fascaplysin has anti-tumor activity against ovarian cancer cell lines through inhibiting CDK4, and may be a therapeutic target for the treatment of ovarian carcinomas."

09/01/2009 - "This study is to investigate the effect of fascaplysin on human cervical cancer cells (HeLa) in order to provide insights into the mechanisms of growth suppression involved in fascaplysin-mediated apoptosis. "
09/01/2009 - "Fascaplysin exhibits anti-proliferation effect towards human cervical cancer HeLa cells through induction of apoptosis via extrinsic death pathway and mitochondrial pathway, but not arresting cell cycle progression at G1 phase. "
09/01/2009 - "[Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction]."