2- methyl- 6,7- dihydroxy- 1,2,3,4- tetrahydroisoquinoline

present in parkinsonian & normal human brains; RN given refers to parent cpd; structure given in first source

Also Known As:

2-MDTIQ; 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide; 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-methylnorsalsolinol; NMNSAL

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline: 3

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 12/01/1997 - "2-MDTIQ may represent an essential factor in the degenerative process of Parkinson's disease." 12/01/1997 - "Thus, 2-MDTIQ is suggested not only to represent an endogenous marker of Parkinson's disease, but also to support changes in the transmitter synthesis of dopaminergic neurons. " 12/01/1997 - "Previous studies of the dopamine metabolism in Parkinson's disease have demonstrated an increased dopamine turnover in the presence of 2-MDTIQ. " 08/01/1995 - "In order to study the relationship between presence of 2-MDTIQ and dopamine metabolism, we examined 3-O-methyl-dopa (MDOPA) and homovanillic acid (HVA) levels in CSF of 15 normal control subjects and 34 patients with Parkinson's disease (PD). "
2.	Parkinsonian Disorders (Parkinsonism) 03/05/1993 - "N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet-Spengler condensation reaction as an alternative metabolic pathway."

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Homovanillic Acid
3.	3-methoxytyrosine
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	Deoxyepinephrine
6.	salsoline