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CGP 39653

NMDA receptor antagonist; structure given in first source

Also Known As:

2-amino-4-propyl-5-phosphono-3-pentenoic acid; CGP-39653; 3-Heptenoic acid, 2-amino-4-(phosphonomethyl)-, (E)-(+-)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - 2-Amino-5-phosphonovalerate: 94
        CGP 39653: 4
  - Phosphoamino Acids: 1
    - 2-Amino-5-phosphonovalerate: 94
      - CGP 39653: 4

Experts

1.	Di Paolo, Thérèse: 1 article (10/2013)
2.	Gasparini, Fabrizio: 1 article (10/2013)
3.	Gomez-Mancilla, Baltazar: 1 article (10/2013)
4.	Grégoire, Laurent: 1 article (10/2013)
5.	Morin, Nicolas: 1 article (10/2013)
6.	Morissette, Marc: 1 article (10/2013)

Related Diseases

1.	Peripheral Nerve Injuries 07/31/1995 - "Binding studies revealed a marked reduction in [3H]CGP-39653 binding at L4-L5 levels ipsilateral to peripheral nerve injury in control transplanted animals. " 07/31/1995 - "In order to determine changes in NMDA receptor expression in the spinal cord following peripheral nerve injury and adrenal medullary grafting, NMDA receptor binding using a high-affinity competitive NMDA receptor antagonist, CGP-39653, and NMDAR1 subunit distribution using immunocytochemistry were investigated. "
2.	Dyskinesias (Dyskinesia) 10/01/2013 - "Elevated basal ganglia specific binding of [(3)H]Ro 25-6981 (NMDA NR1/NR2B receptors), [(3)H]Ro 48-8587 (AMPA receptors) but not [(3)H]CGP-39653 (NMDA NR1/NR2A receptors) was observed only in L-DOPA-treated MPTP monkeys; dyskinesias scores correlated with binding. "
3.	Seizures (Absence Seizure) 10/09/1999 - "Seizures were assessed for 20 min. During pregnancy, the density of the NMDA competitive antagonist site measured by [3H]-CGP 39653 was decreased in the hippocampus, thalamus and hypothalamus (P<0.01), while the glycine modulation site was decreased in the cortex, hippocampus, thalamus, caudate and cerebellum (P<0.01). "
4.	Schizophrenia (Dementia Praecox) 02/25/1999 - "Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Glycine (Aminoacetic Acid)
4.	Glutamic Acid (Glutamate)
5.	AMPA Receptors (AMPA Receptor)
6.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
7.	Levodopa (L Dopa)
8.	Ro 48-8587
9.	Ro 25-6981
10.	NMDA receptor A1