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SCH 42495
Also Known As:
N-(2(S)-(acetylthiomethyl)-3-(2-methylphenyl)-1-oxopropyl)-L-methionine ethyl ester; SCH-42495
Networked:
6
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Sulfur Amino Acids: 221
Methionine: 6648
SCH 42495: 6
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Essential Amino Acids: 1152
Methionine: 6648
SCH 42495: 6
Sulfur Amino Acids: 221
Methionine: 6648
SCH 42495: 6
Neutral Amino Acids: 200
Methionine: 6648
SCH 42495: 6
Experts
1.
Stuhr, L E
: 1 article (04/2000)
Related Diseases
1.
Right Ventricular Hypertrophy
12/01/1994 - "
Treatment with SCH 42495 caused a significant reduction in pulmonary vascular remodelling (25.0 +/- 0.01%) and right ventricular hypertrophy (0.52 +/- 0.09) in CHT20 rats compared with CHV20 controls (33.0 +/- 0.02% and 0.61 +/- 0.09 respectively).
"
2.
Hypertrophy
07/01/1994 - "
4. Treatment with SCH 42495 caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days.
"
3.
Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
04/01/2000 - "
The aim of the present study was to investigate the effects of inhibition of neutral endopeptidase on left ventricular hypertrophy (LVH), myocardial necrosis and haemodynamic changes, previously shown in rats after repeated hyperbaric exposures to 5 bar, by using the novel neutral endopeptidase inhibitor SCH 42495.
"
4.
Necrosis
04/01/2000 - "
The aim of the present study was to investigate the effects of inhibition of neutral endopeptidase on left ventricular hypertrophy (LVH), myocardial necrosis and haemodynamic changes, previously shown in rats after repeated hyperbaric exposures to 5 bar, by using the novel neutral endopeptidase inhibitor SCH 42495.
"
5.
Essential Hypertension
07/01/1993 - "
The detailed integrated renal, hormonal, and hemodynamic effects of acute (first dose) and established (4 days) inhibition of endopeptidase 24.11 by SCH 42495 (200 mg, every 12 hours) were documented in eight patients with essential hypertension in a double-blind, balanced random-order, crossover study.
"
07/01/1993 - "
Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension.
"
11/01/1994 - "
Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension.
"
08/01/1993 - "
The effects of change in posture, pressor infusions of angiotensin II, or inhibition of endopeptidase 24.11 were documented in two groups of patients with essential hypertension receiving one of two orally active inhibitors (SCH 42495 or UK 79300) in double-blind, placebo-controlled, random-order crossover studies.
"
Related Drugs and Biologics
1.
Neprilysin (Neutral Endopeptidase)
2.
Methylcellulose (BFL)
3.
Antihypertensive Agents (Antihypertensives)
4.
Angiotensin II
5.
candoxatril