pertactin

amino acid sequence has been determined; synthesized as a 93kDa precursor; mature pertactin is 68kDa in B. pertussis, 69kDA in B. bronchiseptica, and 70kDA in B. parapertussis

Also Known As:

Bordetella pertussis outer membrane protein P69; OMP p.68, B. bronchiseptica; OMP p.69, B. pertussis; OMP p.70, B. parapertussis; P.70 pertactin; P70 pertactin; PRN protein, Bordetella bronchiseptica; bordetella pertussis pertactin antigen; p.68 pertactin; pertactin p.68; pertactin, Bordetella bronchiseptica; pertactin, Bordetella parapertussis

Networked: 289 relevant articles (17 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	He, Qiushui: 8 articles (01/2021 - 07/2004)
2.	Guiso, Nicole: 8 articles (01/2019 - 11/2005)
3.	McIntyre, Peter: 7 articles (11/2018 - 01/2010)
4.	Mooi, Frits R: 6 articles (01/2020 - 06/2002)
5.	Marshall, Helen: 6 articles (11/2018 - 01/2010)
6.	Mertsola, Jussi: 5 articles (01/2021 - 05/2005)
7.	Bottero, Daniela: 5 articles (01/2021 - 08/2008)
8.	Halperin, Scott A: 5 articles (01/2020 - 12/2005)
9.	van Els, Cécile A C M: 5 articles (01/2020 - 02/2009)
10.	Hozbor, Daniela: 5 articles (11/2019 - 08/2008)

Related Diseases

1.	Whooping Cough (Pertussis) 12/15/2001 - "We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. " 12/15/2001 - "However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. " 01/01/2022 - "pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV." 01/01/2022 - "pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. " 10/01/2021 - "Anti-PT and post-primary anti-PRP antibody concentrations tended to be higher, and anti-HBV, anti-FHA, anti-pertactin from pertussis and post-booster anti-PRP antibody concentrations lower in DT5aP-HBV-IPV-Hib versus DT3aP-HBV-IPV/Hib recipients. "
2.	Infections 01/01/2017 - " In this cohort of predominantly unimmunized infants, clinical disease did not differ between infection with pertactin-deficient and those with pertactin-producing B. " 01/01/2000 - "Antibody patterns over time suggest that antibody to FHA and perhaps to pertactin is stimulated by infections with other organisms, as well as B. " 12/01/1998 - "Subjects with an imputed pertactin value of < 7 EU ml-1 had a 67% (18/27) chance of infection regardless of the PT value. " 12/01/1998 - "The imputed geometric mean antibody values to PT, pertactin and fimbriae-2 at the time of household exposure to Bordetella pertussis infection were higher (p < 0.07 or lower) in non-cases compared with cases. " 01/01/1992 - "Recombinant P.69/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection."
3.	Diphtheria 09/01/2008 - "Compared with the control group, infants in the experimental group demonstrated significantly lower geometric mean antibody concentrations for pertussis toxin and pertactin 6, 7, and 18 months, for fimbrae at 6, 7, 17, and 18 months, and for FHA at 18 months, and lower geometric mean antibody concentrations for diphtheria at 7 months. " 06/06/2011 - "Immunogenicity was assessed pre and post vaccination by ELISA for diphtheria (D), tetanus (T), pertussis toxin (PT), filamentous haemagglutinin (FHA), and pertactin (PRN). " 01/01/2006 - "Significantly higher anti-diphtheria, anti-pertactin (PRN) and anti-polio GMTs were measured following DTPa-HBV-IPV than DTPa-HBV plus IPV. " 01/01/2004 - "After the third immunisation, preterm infants had similar GMCs to controls to diphtheria, tetanus, filamentous haemagglutinin (FHA), and pertactin (PRN), but a significantly lower GMC to pertussis toxin (PT). " 01/01/1994 - "When age of first dose was examined (8-12 weeks versus 16-20 weeks), it was found that young age had a suppressive effect on antibody responses in DTP but not APDT recipients to LPF toxoid, pertactin, fimbriae-2, and tetanus and diphtheria toxoids. "
4.	Tetanus 01/01/2020 - "Antibody concentrations were significantly lower at 7 months of age in females for tetanus and filamentous haemagglutinin and at 13 months of age for pertactin. " 02/04/2011 - "Purified B-cells were characterized by FACS-analysis and after polyclonal stimulation memory B-cells were detected by ELISPOT-assays specific for pertussis toxin, filamentous haemagglutinin, pertactin and tetanus. " 06/06/2011 - "Immunogenicity was assessed pre and post vaccination by ELISA for diphtheria (D), tetanus (T), pertussis toxin (PT), filamentous haemagglutinin (FHA), and pertactin (PRN). " 01/01/2004 - "After the third immunisation, preterm infants had similar GMCs to controls to diphtheria, tetanus, filamentous haemagglutinin (FHA), and pertactin (PRN), but a significantly lower GMC to pertussis toxin (PT). " 01/01/1994 - "When age of first dose was examined (8-12 weeks versus 16-20 weeks), it was found that young age had a suppressive effect on antibody responses in DTP but not APDT recipients to LPF toxoid, pertactin, fimbriae-2, and tetanus and diphtheria toxoids. "
5.	Cough 06/01/2016 - "Fluorescence spectroscopy in combination with multivariate statistical methods was employed as a tool for monitoring the manufacturing process of pertactin (PRN), one of the virulence factors of Bordetella pertussis utilized in whopping cough vaccines. " 07/01/2003 - "In the present study, IgG antibodies against pertactin, pertussis toxin and FHA (determined by ELISA) were compared in 207 individuals with culture-verified pertussis and paroxysmal cough for >/= 21 days. " 04/01/1997 - "When analyzing efficacy based on prevention of laboratory-confirmed pertussis with cough > or = 7 days, single component pertussis toxin (PT) toxoid vaccines were found to be less effective than two-component PT toxoid/filamentous hemagglutinin vaccines, and three- or four-component vaccines containing pertactin in addition to PT toxoid and filamentous hemagglutinin were more effective than either the single-component or two-component vaccines."

Related Drugs and Biologics

1.	Vaccines
2.	Hemagglutinins (Hemagglutinin)
3.	Pertussis Toxin
4.	Antigens
5.	pertussis toxoid
6.	Acellular Vaccines
7.	Diphtheria-Tetanus-acellular Pertussis Vaccines (Tripedia)
8.	Toxoids
9.	Antibodies
10.	Pertussis Vaccine

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Intranasal Administration