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3,4- dihydro- 5- methyl- 1(2H)- isoquinolinone
structure given in first source
Also Known As:
PD 128763; PD-128763; 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
3,4-dihydro-5-methyl-1(2H)-isoquinolinone: 1
Related Diseases
1.
Leukemia L1210
01/01/1992 - "
The cytotoxic activity of streptozotocin in L1210 leukemia cells was maximally potentiated (7-fold decrease in IC50) under conditions of 24 hr exposure to PD 128763 following treatment with the alkylating agent for 1 hr. Similar treatment conditions resulted in a much greater effect (36-fold enhancement in activity) for the 2-nitroimidazole RSU 1069.
"
Related Drugs and Biologics
1.
Streptozocin (Streptozotocin)
2.
Alkylating Agents
3.
1- (2- nitro- 1- imidazolyl)- 3- aziridino- 2- propanol
4.
azomycin