alatriopril

shows promise for the treatment of various cardiovascular & salt-retention disorders

Also Known As:

N-(3-(3,4-methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxopropyl)-(S)-alanine benzyl ester; L-Alanine, N-(3-(acetylthio)-2-(1,3-benzodioxol-5-ylmethyl)-1-oxopropyl)-, phenylmethyl ester, (S)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - alatriopril: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - alatriopril: 2

Related Diseases

1.	Heart Failure 07/01/1994 - "The aim of the study was to compare, in a rat model of congestive heart failure, the effect of captopril, a selective angiotensin-converting enzyme (ACE; EC 3.4.15.1) inhibitor, to that of alatriopril, a mixed inhibitor of ACE and atriopeptidase (EC 3.4.24.11), an enzyme implicated in the degradation of atrial natriuretic factor (ANF). "
2.	Myocardial Infarction 07/01/1994 - "Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. "
3.	Hypertrophy 07/01/1994 - "The hypertrophy of right ventricle was reduced by 47% with alatriopril and by 35% with captopril (N.S.), whereas the corresponding reductions for atria were 47% vs. 21% (P < .05). "
4.	Cardiomegaly (Heart Hypertrophy) 07/01/1994 - "Both treatments significantly reduced cardiac hypertrophy, but alatriopril showed a greater efficacy than captopril--the increase in relative heart weight reaching 38% with captopril and only 22% with alatriopril (P < .05). " 07/01/1994 - "Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. "
5.	Body Weight (Weight, Body) 05/15/1991 - "In vitro the two compounds inhibit both ACE and enkephalinase activities with similar, nanomolar potencies, and in vivo, glycopril and alatriopril, the corresponding diester prodrugs, occupy the two enzyme molecules in lung at similar low dosages (0.2-0.5 mg/kg of body weight, per os). "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Enzymes
3.	Atrial Natriuretic Factor (ANF)
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
5.	Captopril (Capoten)
6.	Prodrugs
7.	glycopril