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barbourin

a GPIIb-IIIa-specific integrin antagonist form the venom of Sisturus M. barbouri; amino acid sequence given in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Snake Venoms: 1139
    - Viper Venoms: 122
      - Crotalid Venoms: 67
        barbourin: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Snake Venoms: 1139
      - Viper Venoms: 122
        Crotalid Venoms: 67
        barbourin: 4

Experts

1.	Jing, Jian: 1 article (09/2005)
2.	Lu, Shan: 1 article (09/2005)

Related Diseases

1.	Pulmonary Embolism 03/01/1996 - "Images of DVT obtained with 123I-bitistatin were focally positive within 1 hr and improved by 4 hr. In pulmonary emboli, the absolute uptake of 123I-bitistatin (0.64 +/- 0.17% ID/g) was higher than all other compounds (p < 0.05), although barbourin had moderate uptake (0.23 +/- 0.11% ID/g) and may also be useful for imaging pulmonary embolism (PE). "
2.	Thrombosis (Thrombus) 11/01/1998 - "In vivo, kistrin and barbourin had significantly lower thrombus:muscle and pulmonary embolus:lung ratios in images compared with bitistatin. " 09/01/2005 - "An eight amino acid sequence, CAKGDWNC, from disintegrin barbourin, was introduced into an inactive human proinsulin molecule between the B28 and A2 sites to construct a chimeric, anti-thrombosis recombinant protein. "
3.	Neoplasms (Cancer) 01/01/1995 - "A major contribution of albolabrin, barbourin and echistatin appears to be by interference with other integrin receptors on the tumor cell surface. " 01/01/1995 - "When injected 1 h after tumor cells, albolabrin, echistatin and barbourin had the same antimetastatic activity, while eristostatin was not active. " 01/01/1995 - "Eristostatin (IC50 7-8 nM) was more potent than echistatin (IC50 74-75 nM), barbourin (IC50 46-60 nM), and albolabrin (IC50 130-165 nM) as an inhibitor of murine platelet aggregation induced by ADP or tumor cells. "
4.	Neoplasm Metastasis (Metastasis) 01/01/1995 - "Four disintegrins, eristostatin, albolabrin, barbourin and echistatin, injected IV into C57BL/6 mice in combination with B16F10 murine melanoma cells, inhibited formation of experimental lung metastases with ID50s of 0.05, 1.0, 0.9, and 3.7 mumoles per mouse, respectively. "
5.	Melanoma (Melanoma, Malignant) 01/01/1995 - "Adhesion of melanoma cells to albolabrin, echistatin, and barbourin was partially inhibited by monoclonal antibody against mouse alpha v subunit. " 01/01/1995 - "Four disintegrins, eristostatin, albolabrin, barbourin and echistatin, injected IV into C57BL/6 mice in combination with B16F10 murine melanoma cells, inhibited formation of experimental lung metastases with ID50s of 0.05, 1.0, 0.9, and 3.7 mumoles per mouse, respectively. "

Related Drugs and Biologics

1.	Disintegrins
2.	Integrins
3.	Recombinant Proteins
4.	Proinsulin
5.	Monoclonal Antibodies
6.	Adenosine Diphosphate (ADP)
7.	eristostatin
8.	kistrin
9.	albolabrin
10.	bitistatin