|1.||Kadomatsu, Kenji: 42 articles (08/2015 - 01/2002)|
|2.||Muramatsu, Takashi: 41 articles (02/2014 - 01/2002)|
|3.||Tagawa, Masatoshi: 16 articles (12/2015 - 01/2002)|
|4.||Muramatsu, T: 15 articles (03/2005 - 01/2000)|
|5.||Muramatsu, Hisako: 14 articles (11/2015 - 01/2002)|
|6.||Kadomatsu, K: 14 articles (02/2014 - 01/2000)|
|7.||Ikematsu, Shinya: 13 articles (12/2013 - 01/2003)|
|8.||Sato, Waichi: 11 articles (08/2015 - 01/2002)|
|9.||Sakuma, Sadatoshi: 11 articles (10/2009 - 03/2003)|
|10.||Takei, Yoshifumi: 10 articles (03/2011 - 04/2002)|
01/01/2015 - "Recent studies have shown that Midkine is up-regulated in several types of human cancers. "
09/01/2010 - "The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. "
04/01/2006 - "The present study was performed to utilize anti-midkine antibody for tumor therapy. "
11/01/1996 - "Recent studies have implicated a role for midkine (MK) in cancer progression. "
10/01/2015 - "In various cancers, high expression of midkine is associated with aggressive clinical behavior and a poor prognosis. "
02/15/2013 - "In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic ganglia. "
10/01/2008 - "The present study evaluated the plasma midkine level in human neuroblastoma patients. "
02/01/2014 - "These results indicate that neuroblastoma cells are highly dependent on midkine and that a midkine-targeted therapy could exert a significant effect in these cells. "
02/01/2014 - "In contrast to these tumours, midkine was found to be expressed in every neuroblastoma cell line tested and the knockdown of midkine alone was sufficient to suppress their growth. "
02/01/2014 - "Involvement of midkine in neuroblastoma tumourigenesis."
08/01/2008 - "The mechanism of inhibition of intimal hyperplasia might be associated with midkine suppression."
06/01/2008 - "Knockdown of midkine expression suppresses neointimal hyperplasia. "
06/01/2008 - "Neointimal hyperplasia is strikingly suppressed in an endothelium injury model in mice deficient in the growth factor midkine. "
09/05/2015 - "Even though midkine has been shown to have cardiac protective effects against acute ischemia/reperfusion injury and to inhibit cardiac remodeling, it also promotes intimal hyperplasia and vascular stenosis. "
08/01/2008 - "In this study, the efficacy of pitavastatin was evaluated on intimal hyperplasia and midkine expression of experimental normocholesterolemic rabbit autologous vein graft. "
|4.||Hypertension (High Blood Pressure)
04/01/2010 - "Conversely, supplemental administration of midkine to the deficient mice induces hypertension. "
06/01/2009 - "Furthermore, hypertension was not induced and renal damage was less severe in midkine-deficient mice. "
04/01/2010 - "Hypertension associated with 5/6 nephrectomy is not observed in midkine-deficient mice. "
06/01/2009 - "Supplemental administration of midkine protein to midkine-deficient mice restored ACE expression in the lung and hypertension after 5/6 nephrectomy. "
02/01/2014 - "Midkine in nephrogenesis, hypertension and kidney diseases."
02/01/2014 - "Midkine and multiple sclerosis."
06/01/2014 - "Correlation of midkine serum level with pro- and anti-inflamatory cytokines in multiple sclerosis."
01/01/2010 - "Midkine inhibitors are expected to be effective in the treatment of malignancies, rheumatoid arthritis, multiple sclerosis, renal diseases, restenosis, hypertension and adhesion after surgery."
02/01/2014 - "Therefore, midkine itself is expected to be useful for the treatment of brain and heart diseases, while midkine inhibitors are promising for the treatment of malignant tumors, multiple sclerosis, restenosis, renal diseases, hypertension and osteoporosis. "
12/01/1998 - "To assess the expression pattern and possible function in multiple sclerosis, the heparin-binding growth factors pleiotrophin (PTN), midkine (MK), basic fibroblast growth factor (FGF-2) and one of its receptors (FGFR1/flg) mRNA and protein levels were examined in an experimental autoimmune encephalomyelitis (EAE) model in the Lewis rat. "
|1.||Intercellular Signaling Peptides and Proteins (Growth Factors)
|2.||Tretinoin (Retinoic Acid)
|7.||RNA (Ribonucleic Acid)
|8.||Heparitin Sulfate (Heparan Sulfate)
|2.||Heterologous Transplantation (Xenotransplantation)