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liver regeneration factor 1

a leucine-zipper protein that is rapidly & highly induced in regenerating liver; MW 21 kDa; amino acid sequence given in first source

Also Known As:

LRF-1; LRF1 transcription factor

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic-Leucine Zipper Transcription Factors: 187
      - Activating Transcription Factors: 32
        Activating Transcription Factor 3: 293
        liver regeneration factor 1: 2
  - DNA-Binding Proteins: 2009
    - Basic-Leucine Zipper Transcription Factors: 187
      - Activating Transcription Factors: 32
        Activating Transcription Factor 3: 293
        liver regeneration factor 1: 2

Related Diseases

1.	Hyperplasia 02/20/1997 - "To further investigate the relationship between immediate early genes and hepatocyte proliferation, we have compared the hepatic levels of c-fos, c-jun and LRF-1 transcripts during mouse liver cell proliferation in two conditions: (i) direct hyperplasia induced by the non-genotoxic hepatocarcinogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, and (ii) compensatory regeneration caused by a necrogenic dose of carbon tetrachloride. "
2.	Hepatocellular Carcinoma (Hepatoma) 02/27/1996 - "During progression, LRF-1 and ets-2 showed a 2- to 3-fold higher expression in persistent nodules and hepatocellular carcinomas than in the corresponding surrounding liver tissues, whereas the expression of the jun genes was 3- to 4-fold increased both in lesions and in surrounding livers when compared to age-matched control rats. "

Related Drugs and Biologics

1.	Carbon Tetrachloride (Tetrachloromethane)
2.	Benzene (Benzole)