plumericin

from bark of Plumeria rubra; structure given in first source; RN given refers to (3aS-(3E,3aalpha,4abeta,7abeta,9aR*,9bbeta))-isomer; RN for cpd without isomeric designation not avail 5/91

Also Known As:

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stuppner, Hermann: 3 articles (01/2021 - 02/2016)
2.	Autore, Giuseppina: 2 articles (01/2021 - 01/2020)
3.	Cuzzocrea, Salvatore: 2 articles (01/2021 - 01/2020)
4.	D'Amico, Ramona: 2 articles (01/2021 - 01/2020)
5.	Di Paola, Rosanna: 2 articles (01/2021 - 01/2020)
6.	Marzocco, Stefania: 2 articles (01/2021 - 01/2020)
7.	Siracusa, Rosalba: 2 articles (01/2021 - 01/2020)
8.	Waltenberger, Birgit: 2 articles (01/2020 - 02/2016)
9.	Cordaro, Marika: 1 article (01/2021)
10.	Fusco, Roberta: 1 article (01/2021)

Related Diseases

1.	Colitis 01/01/2020 - "Using the DNBS-induced colitis model, a significant reduction in the weight loss and in the development of the macroscopic and histologic signs of colon injury, together with a reduced inflammatory and oxidative stress state, were observed in plumericin-treated mice. " 01/12/2021 - "Plumericin was evaluated for its ability to improve barrier function and to reduce apoptotic parameters during inflammation, both in intestinal epithelial cells (IEC-6), and in an animal experimental model of 2, 4, 6-dinitrobenzene sulfonic acid (DNBS)-induced colitis. " 01/01/2020 - "Moreover, a 2,4,6-dinitrobenzene sulfonic acid (DNBS)-induced colitis model was used to evaluate the anti-inflammatory and antioxidant activity of plumericin (3 mg/kg) in vivo. " 01/12/2021 - "Plumericin reduced the activity of myeloperoxidase, inhibited the expression of ICAM-1, P-selectin, and the formation of PAR, and reduced apoptosis parameters in mice colitis induced by DNBS. "
2.	Weight Loss (Weight Reduction) 01/01/2020 - "Using the DNBS-induced colitis model, a significant reduction in the weight loss and in the development of the macroscopic and histologic signs of colon injury, together with a reduced inflammatory and oxidative stress state, were observed in plumericin-treated mice. "
3.	Inflammation (Inflammations) 01/01/2020 - "In this study, we evaluated the effect of plumericin, one of the main bioactive components of Himatanthus sucuuba (Woodson) bark, on intestinal inflammation and oxidative stress, both in vitro and in vivo. " 01/01/2020 - "Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo." 04/01/2014 - "Here we report the characterization of the natural product plumericin as a highly potent inhibitor of the NF-κB pathway with a novel chemical scaffold, which was isolated via a bioactivity-guided approach, from extracts of Himatanthus sucuuba, an Amazonian plant traditionally used to treat inflammation-related disorders. " 02/09/2016 - "Hence, plumericin, by targeting at least two culprits of vascular dysfunction -inflammation and smooth muscle cell proliferation -might become a promising electrophilic lead compound for vascular disease therapy. " 01/12/2021 - "Plumericin was evaluated for its ability to improve barrier function and to reduce apoptotic parameters during inflammation, both in intestinal epithelial cells (IEC-6), and in an animal experimental model of 2, 4, 6-dinitrobenzene sulfonic acid (DNBS)-induced colitis. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/12/2021 - "Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis."
5.	Vascular Diseases (Vascular Disease) 02/09/2016 - "Hence, plumericin, by targeting at least two culprits of vascular dysfunction -inflammation and smooth muscle cell proliferation -might become a promising electrophilic lead compound for vascular disease therapy. "

Related Drugs and Biologics

1.	2,4-dinitrofluorobenzene sulfonic acid
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	Sulfonic Acids
4.	E-Selectin
5.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
6.	P-Selectin
7.	Peroxidase (Myeloperoxidase)
8.	Luciferases
9.	Antioxidants

Related Therapies and Procedures

1.	Therapeutics