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3-aminopropyl(methyl)phosphinic acid

structure given in first source; GABA-A receptor antagonist

Also Known As:

3-APMPA; SK&F 97541; SKF-97541; SKF97541

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - 3-aminopropyl(methyl)phosphinic acid: 5

Experts

1.	Coop, Andrew: 2 articles (06/2007 - 06/2005)
2.	Koek, Wouter: 2 articles (06/2007 - 06/2005)
3.	Mareš, Pavel: 1 article (06/2012)
4.	Mares, Pavel: 1 article (01/2008)
5.	Tabashidze, Nana: 1 article (01/2008)
6.	Mares, P: 1 article (01/2008)
7.	Mercer, Susan L: 1 article (06/2007)
8.	Carter, Lawrence P: 1 article (06/2005)
9.	Chen, Weibin: 1 article (06/2005)
10.	France, Charles P: 1 article (06/2005)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2008 - "SKF97541 blocked the appearance of minimal clonic seizures, but tended to decrease latencies of both types of seizures. " 01/31/2008 - "Suppression of intensity of both motor phenomena (movements and clonic seizures) was marked with SKF97541 in 12- and 18-day-old rats; this effect was only marginal in baclofen-treated animals. " 01/31/2008 - "SKF97541 was able to increase threshold intensities of stimulation current necessary for elicitation of movements directly bound to stimulation, spike-and-wave type of ADs and accompanying clonic seizures in 12- and 18-day-old rats, baclofen was without effect. " 06/01/2012 - "Possible anticonvulsant action of CGP7930 was studied in a model of pentetrazol-induced seizures previously used for studies with agonists baclofen and SKF97541. "
2.	Catalepsy 06/01/2007 - "In C57BL/6J mice, GHB, the GHB precursor gamma-butyrolactone (GBL), and the GABA(B) receptor agonists baclofen and SKF97541 all produced catalepsy but differed in potency (i.e., SKF97541>baclofen>GBL>GHB) and in onset of action. " 06/01/2005 - "The GABA(B) receptor antagonist CGP35348 (3-aminopropyl(diethoxymethyl)phosphinic acid) attenuated catalepsy and ataxia that was observed after GHB and GABA(B) receptor agonists SKF97541 and baclofen. " 06/01/2005 - "In mice, GHB, GHB precursors (gamma-butyrolactone and 1,4-butanediol) and GABA(B) receptor agonists [SKF97541 [3-aminopropyl(methyl)phosphinic acid hydrochloride] and baclofen] dose-dependently produced hypolocomotion, catalepsy, ataxia, and loss of righting. "
3.	Ataxia (Dyssynergia) 06/01/2005 - "The GABA(B) receptor antagonist CGP35348 (3-aminopropyl(diethoxymethyl)phosphinic acid) attenuated catalepsy and ataxia that was observed after GHB and GABA(B) receptor agonists SKF97541 and baclofen. " 06/01/2005 - "In mice, GHB, GHB precursors (gamma-butyrolactone and 1,4-butanediol) and GABA(B) receptor agonists [SKF97541 [3-aminopropyl(methyl)phosphinic acid hydrochloride] and baclofen] dose-dependently produced hypolocomotion, catalepsy, ataxia, and loss of righting. "

Related Drugs and Biologics

1.	Baclofen
2.	Anticonvulsants (Antiepileptic Drugs)
3.	2,6- di- tert- butyl- 4- (3- hydroxy- 2,2- dimethylpropyl)phenol
4.	GABA-B Receptor Agonists
5.	GABA-B Receptor Antagonists
6.	4-Butyrolactone (gamma Butyrolactone)
7.	Phosphinic Acids (Phosphinic Acid)