GE 2270 A

from Planobispora rosea; inhibits bacterial protein synthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu; structure given in first source

Also Known As:

GE 2770; GE-2270; GE-2270A; GE2270; GE2270 A; GE2270A; MDL 62879; MDL-62879

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - GE 2270 A: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - GE 2270 A: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - GE 2270 A: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - GE 2270 A: 2

Experts

1.	Breitling, Rainer: 1 article (06/2021)
2.	Del Carratore, Francesco: 1 article (06/2021)
3.	Donadio, Stefano: 1 article (06/2021)
4.	Genilloud, Olga: 1 article (06/2021)
5.	Gyulev, Ivan S: 1 article (06/2021)
6.	Iorio, Marianna: 1 article (06/2021)
7.	Macdonald, Sandy J: 1 article (06/2021)
8.	Pérez-Bonilla, Mercedes: 1 article (06/2021)
9.	Pérez-Redondo, Rosario: 1 article (06/2021)
10.	Rodríguez-García, Antonio: 1 article (06/2021)

Related Diseases

1.	Clostridium Infections 06/29/2021 - "GE2270A is a potent thiopeptide antibiotic currently used as a precursor for the synthesis of two compounds under clinical studies for the treatment of Clostridium difficile infection and acne. "
2.	Acne Vulgaris 06/29/2021 - "GE2270A is a potent thiopeptide antibiotic currently used as a precursor for the synthesis of two compounds under clinical studies for the treatment of Clostridium difficile infection and acne. "
3.	Gram-Positive Bacterial Infections 12/08/2011 - "4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their activity against Gram positive bacterial infections. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)