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reveromycin A

from an actinomycete strain; structure given in first source; inhibits the mitogenic activity of the epidermal growth factor
Networked: 12 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Osada, Hiroyuki: 8 articles (01/2015 - 10/2002)
2. Kawatani, Makoto: 4 articles (01/2015 - 12/2005)
3. Tabuchi, Masako: 2 articles (01/2015 - 09/2013)
4. Maeda, Hatsuhiko: 2 articles (01/2015 - 09/2013)
5. Yoshizako, Mamoru: 2 articles (01/2015 - 09/2013)
6. Tanaka, Miyuki: 2 articles (01/2015 - 09/2013)
7. Goto, Shigemi: 2 articles (01/2015 - 09/2013)
8. Miyazawa, Ken: 2 articles (01/2015 - 09/2013)
9. Sone, Saburo: 2 articles (12/2007 - 12/2005)
10. Yano, Seiji: 2 articles (12/2007 - 12/2005)

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Lung Neoplasms (Lung Cancer)
3. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
4. Neoplasms (Cancer)
12/15/2005 - "Histologic analyses revealed that although treatment with reveromycin A did not affect the number of proliferating tumor cells, it decreased the number of osteoclasts and increased apoptotic cells in bone lesions. "
07/01/2011 - "Here we comprehensively describe the spiroacetal formation involved in the biosynthesis of reveromycin A, which inhibits bone resorption and bone metastases of tumor cells by inducing apoptosis in osteoclasts. "
12/15/2005 - "These findings suggest that reveromycin A may inhibit osteolytic bone metastasis through suppression of osteoclast activity by directly inducing apoptosis and indirectly inhibiting tumor cell-derived parathyroid hormone-related peptide production. "
10/07/2008 - "Both kinases are key drivers of osteoclast maturation, and three agents that block osteoclastogenesis, the Src inhibitor dasatinib, the bisphosphonate alendronate, and the osteoclast-specific apoptosis-inducer reveromycin A, markedly reduced 17-AAG-stimulated tumor growth in bone. "
01/01/1997 - "The antitumor effect of reveromycin A (RM-A), an inhibitor of EGF-dependent cell proliferation on murine and human tumor cell lines, was examined in vitro and in vivo, RM-A showed little antitumor effect against three murine tumors tested, but showed strong antitumor effect (a minimum treated/control ratio of 36%) against a human ovarian carcinoma BG-1, which is known to be a transforming growth factor alpha (TGF-alpha)-secreting and estrogen receptor-expressing cell line. "
5. Bone Resorption

Related Drugs and Biologics

1. Diphosphonates
2. Osteoprotegerin
3. Parathyroid Hormone-Related Protein
4. Alendronate (Alendronate Sodium)
5. Transforming Growth Factor alpha (TGF-alpha)
6. Antigen Receptors (Antigen Receptor)
7. Phosphotransferases (Kinase)
8. Estrogens (Estrogen)
9. Epidermal Growth Factor (EGF)
10. Antigens