|1.||Thompson, John A: 2 articles (10/2005 - 08/2002)|
|2.||Nandakumar, Manjula: 1 article (07/2015)|
|3.||Lin, Chun-Hung: 1 article (07/2015)|
|4.||Lo, Lee-Chiang: 1 article (07/2015)|
|5.||Lin, Jason C-Y: 1 article (07/2015)|
|6.||Lo, Chun: 1 article (07/2015)|
|7.||Hsu, Yu-Ling: 1 article (07/2015)|
|8.||Davis, Angela L: 1 article (01/2015)|
|9.||Qiao, Shuxi: 1 article (01/2015)|
|10.||Cabello, Christopher M: 1 article (01/2015)|
01/14/2011 - "Oxidation to a reactive quinone methide is the mechanistic basis of many phenolic anti-cancer drugs. "
01/01/2005 - "Among these anti-tumor agents, one mechanism was involved in quinone methide intermediate. "
09/01/2004 - "Tumor cells were highly sensitive to 2-methoxy-4-alkylphenols such as EUG and MMP, possibly due to the formation of cytotoxic quinone methide intermediates. "
03/07/2001 - "Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion."
01/01/2015 - "Quinone methide and cinnamaldehyde act in a synergistic manner to amplify oxidative stress, leading to preferential killing of cancer cells in vitro and in vivo. "
07/27/2015 - "Detection of Human α-L-Fucosidases by a Quinone Methide-Generating Probe: Enhanced Activities in Response to Helicobacter pylori Infection."
07/27/2015 - "To study the enzymatic activity change under pathological conditions, we developed a quinone methide-generating activity-based probe useful for examining the presence, activity, and localization of human α-L-fucosidase in vivo in the context of Helicobacter pylori infection. "
|3.||Melanoma (Melanoma, Malignant)
08/15/2010 - "TMECG is specifically activated in melanoma cells to form a stable quinone methide (TMECG-QM). "
05/01/2006 - "Covalent modification of a melanoma-derived antigenic peptide with a natural quinone methide. "
01/16/2015 - "Taken together, our data suggest feasibility of apoptotic elimination of malignant melanoma cells using the quinone methide-derived heat shock response inducer aurin. "
01/16/2015 - "The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells."
06/05/2002 - "Formation of quercetin quinone/quinone methide metabolites, reflected by formation of the glutathionyl quercetin adducts as authentic metabolites, was investigated in an in vitro cell model (B16F-10 melanoma cells). "
|4.||Dehydration (Water Stress)
05/18/2012 - "Excitation of QMP 5 to S(1) leads to efficient excited state intramolecular proton transfer (ESIPT) coupled with dehydration, giving quinone methide QM5 which was characterized by LFP (in CH(3)CN-H(2)O, λ(max) = 370 nm, τ = 0.19 ms). "
08/01/2006 - "The formation of a unique glutathione adduct was observed in rat bile, which was proposed to occur via N-dealkylation, followed by reduction of the putative aldehyde product to form the alcohol, and dehydration of the alcohol to generate a reactive quinone methide intermediate. "
06/01/2007 - "In the ZT process, slow addition permitted polymer reorganisation which led to dehydration around the lignin-like growing chains thereby limiting the addition of water on the quinone methide formed during polymerisation and thus favoured lignin-carbohydrate complex (LCC) formation."
05/14/2012 - "By contrast, in presence of glucose, anthrahydroquinone units (formed by reduction of AQ) reduced the quinone-methide units (issued by dehydration of phenolic β-O-4 lignin model part) mainly by electron transfer leading to guaiacol as major product. "
|5.||Autoimmune Diseases (Autoimmune Disease)
11/01/2011 - "Celastrol is a quinone methide triterpene derived from the medicinal plant Tripterygium wilfordii, which has been used to treat chronic inflammatory and autoimmune diseases. "
04/09/2010 - "Celastrol, a quinone methide triterpene, is a pharmacologically active compound present in Thunder God Vine root extracts used as a remedy of inflammatory and autoimmune diseases, e.g. "
04/01/2007 - "Celastrol, a quinone methide triterpene derived from the medicinal plant Tripterygium wilfordii, has been used to treat chronic inflammatory and autoimmune diseases, but its mechanism is not well understood. "
|1.||Butylated Hydroxytoluene (BHT)
|4.||Hydrogen Peroxide (Hydroperoxide)
|5.||Glutathione (Reduced Glutathione)
|7.||Ornithine Decarboxylase (Decarboxylase, Ornithine)
|10.||2,6- di- tert- butyl- 4- hydroperoxy- 4- methyl- 2,5- cyclohexadienone