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GR 73632

neurokinin receptor agonist
Also Known As:
GR-73632; GR73632; delta-aminovaleryl-9-Pro-10-MeLeu-substance P (7-10); substance P (7-10), delta-aminovaleryl-Pro(9)-N-MeLeu(10)-; substance P (7-10),delta-aminovaleryl-prolyl(9)-N-methylleucine(10)-; L-Methioninamide, N-(5-amino-1-oxopentyl)-L-phenylalanyl-L-phenylalanyl-L-prolyl-N-methyl-L-leucyl-
Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Darmani, Nissar A: 4 articles (05/2014 - 06/2008)
2. Chebolu, Seetha: 3 articles (05/2014 - 06/2009)
3. Ramirez, Juan: 2 articles (06/2009 - 06/2008)
4. Ray, Andrew P: 2 articles (06/2009 - 06/2008)
5. Zhong, Weixia: 1 article (05/2014)
6. Alkam, Tursun: 1 article (10/2011)
7. Amos, Barry: 1 article (10/2011)
8. Wang, Yaozhi: 1 article (06/2008)
9. Abad, Joseph: 1 article (06/2008)
10. Thrush, Gerald R: 1 article (06/2008)

Related Diseases

1. Vomiting
06/01/2009 - "After 3 days, shrews were challenged intraperitoneally with the emetogenic NK agonist GR73632 at different doses, and vomiting and scratching behaviors were quantified. "
06/12/2008 - "Ablation of peripheral NK1 receptors attenuated the ability of GR73632 to induce a maximal frequency of emesis and shifted its percent animals vomiting dose-response curve to the right. "
06/12/2008 - "The results clearly demonstrated that while SP produced vomiting only, GR73632 caused both emesis and scratching behavior dose-dependently in shrews, and these effects were sensitive to NK1-, but not NK2- or NK3-receptor antagonists. "
06/12/2008 - "SarMet-SP) NK1 receptor agonist, an NK2 receptor agonist (GR64349), or an NK3 receptor agonist (Pro7-NKB), would induce vomiting and/or scratching in the least shrew (Cryptotis parva) in a dose-dependent manner; and whether these effects are sensitive to the above selective receptor antagonists; 2) whether an exogenous emetic dose of SP (50 mg/kg, i.p.) can penetrate into the shrew brain stem and frontal cortex; 3) whether GR73632 (2.5 mg/kg, i.p.)-induced activation of NK1 receptors increases Fos-measured neuronal activity in the neurons of both brain stem emetic nuclei and the enteric nervous system of the gut; and 4) whether selective ablation of peripheral NK1 receptors can affect emesis produced by GR73632. "
06/01/2009 - "Although SSP-SAP injection reduced emesis at GR73632 doses of 2.5 and 5 mg/kg, no injections completely eliminated emesis. "
2. Radiation Injuries (Radiation Sickness)
3. Pain (Aches)
4. Hyperalgesia
5. Edema

Related Drugs and Biologics

1. Substance P
2. Formaldehyde (Formol)
3. Quinpirole
4. Amlodipine (Norvasc)
5. Tachykinins
6. Serotonin (5 Hydroxytryptamine)
7. Pilocarpine (Ocusert)
8. (4- (m- Chlorophenylcarbamoyloxy)- 2- butynyl)trimethylammonium Chloride
9. p-Methoxy-N-methylphenethylamine
10. Cisplatin (Platino)

Related Therapies and Procedures

1. Injections
2. Spinal Injections