lifarizine

sodium-calcium channel modulator; reduces ischemic brain damage

Also Known As:

1-((2-(4-methylphenyl)-5-methyl)-1H-imidazol-4-ylmethyl)-4-diphenylmethylpiperazine; RS 87476; RS-87476; lyfarizine

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - lifarizine: 8
  - Piperazines: 26
    - lifarizine: 8

Related Diseases

1.	Hypotension (Low Blood Pressure) 12/01/1995 - "1. A new, modified rat two vessel occlusion model (with hypotension) was established and the neuroprotective efficacy of the novel agent lifarizine (RS-87476) was examined. " 11/01/1997 - "These clinical effects include hypertension (which is probably preferable to the hypotension seen with nimodipine and lifarizine), sedation, confusion or hallucinations and, at high doses, catatonia. "
2.	Neuroblastoma 10/01/1994 - "1. The ability of lifarizine (RS-87476) to block human voltage-sensitive Na+ channel currents was studied by use of whole cell patch clamp recording from differentiated neuroblastoma cells (SH-SY5Y). " 04/01/1995 - "1. The actions of the neuroprotective agent, lifarizine (RS-87476-190), on voltage-dependent Na+ currents have been examined in the neuroblastoma cell line, N1E-115, using the whole-cell variant of the patch clamp technique. " 07/01/1995 - "5. The potencies of a series of compounds in displacing [3H]-lifarizine from rat cerebrocortical membranes correlated well with their affinities for inactivated sodium channels estimated from whole-cell voltage clamp studies in the mouse neuroblastoma cell line, NIE-115 (r=0.96).6. These results show that [3H]-lifarizine is a high affinity ligand for neuronal sodium channels which potently and selectively labels a site, allosterically linked to toxin binding site 2, associated within activated sodium channels." 04/01/1995 - "Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115."
3.	Infarction (Infarctions) 04/01/1991 - "Compared with infarcts in placebo-treated animals, infarcts in cats given RS-87476 were reduced by an average of 70% at the lowest dose, 75% at the intermediate dose, and 88% at the highest dose. " 02/01/1998 - "2. Lifarizine, ipsapirone and N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) all reduced both infarct area and volume. "
4.	Hypertension (High Blood Pressure) 11/01/1997 - "These clinical effects include hypertension (which is probably preferable to the hypotension seen with nimodipine and lifarizine), sedation, confusion or hallucinations and, at high doses, catatonia. "
5.	Hallucinations (Hallucination) 11/01/1997 - "These clinical effects include hypertension (which is probably preferable to the hypotension seen with nimodipine and lifarizine), sedation, confusion or hallucinations and, at high doses, catatonia. "

Related Drugs and Biologics

1.	Sodium Channels (Sodium Channel)
2.	Ligands
3.	Sodium
4.	Lactic Acid (Lactate)
5.	Neuroprotective Agents
6.	Calcium Channels (Calcium Channel)
7.	Nimodipine (Modus)
8.	ipsapirone
9.	tesmilifene (DPPE)