|1.||Liu, M H: 1 article (09/2001)|
|2.||Yang, Q: 1 article (09/2001)|
|3.||He, G W: 1 article (09/2001)|
|4.||Floten, S H: 1 article (09/2001)|
|1.||Hypertension (High Blood Pressure)
07/01/1993 - "The above results suggest that monatepil is a highly safe drug in the treatment of hypertension."
10/01/1994 - "The efficacy of monatepil, a new calcium antagonist, in the treatment of essential hypertension."
10/01/1994 - "The effects of monatepil, a new calcium antagonist with alpha 1-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in 86 patients with mild-to-moderate hypertension were examined in a randomized, open-label, multicenter (32 hospitals) study. "
10/01/1994 - "Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension."
10/01/1994 - "However, the long-term effects of monatepil on the progression of atherosclerosis remain to be determined."
10/01/1994 - "Noninvasive quantitative evaluation of early atherosclerosis and the effect of monatepil, a new antihypertensive agent. "
03/01/1994 - "9. In conclusion, monatepil is a new class of antihypertensive agent that possesses anti-atherogenic properties and the ability to reduce plasma lipid levels, a main risk factor for atherosclerosis."
10/01/1994 - "In two studies on the same group of patients we evaluated noninvasive methods of assessing atherosclerosis and determined the effect of the new calcium channel-blocking agent monatepil on the progression of early atherosclerosis in humans. "
04/01/1996 - "These results indicate that AJ-2615 has the same potent antioxidative effect as probucol and suggest that a previously reported ability of AJ-2615 to inhibit the progression of atherosclerosis may be due to this antioxidative property. "
11/01/1998 - "The mechanism of the prophylactic effect against hyperlipidemia by monatepil maleate was investigated in animal models. "
07/01/1997 - "These results suggest that ACAT-inhibiting effect of monatepil maleate plays an important role in the reduction of hyperlipidemia."
03/01/1994 - "1. The preventive effects of atherosclerosis and hyperlipidemia of monatepil ([(+-)-N-(6,11-dihydrodibenzo [b,e]thiepin-11-yl)-4-(4-fluorophenyl)-1-piperazine-butanamide+ + +]monomaleate , AJ-2615, CAS 103377-41-9), a new antihypertensive drug with potent calcium antagonistic and alpha 1-adrenoceptor blocking activities, were investigated in Japanese monkeys (Macaca fuscata) fed with a cholesterol-rich diet (2% cholesterol + 6% corn oil) and compared with those of prazosin. "
05/01/1993 - "These results suggested that AJ-2615 has potential as a long-acting (once daily dosage regimen) antihypertensive drug without causing a steep blood pressure fall and tachycardia."
07/01/1993 - "AJ-2615 (0.1 mg/kg per min for 2 min, i.v.) also suppressed atrial tachycardia induced by aconitine (0.01% aconitine solution) in rats. "
|5.||Myocardial Ischemia (Ischemic Heart Diseases)
06/01/1994 - "Preventive effect of monatepil on thromboxane A2 agonist-induced myocardial ischemia in rats."
06/01/1994 - "Antianginal effects of monatepil ([(+-)-N-(6,11-dihydrodibenzo[b,e]thiepin-11-yl)-4-(4-fluor ophenyl)-1-piperazinebutanamide]monomaleate, AJ-2615, CAS 10337-41-9), a new calcium antagonist, were evaluated in experimentally induced myocardial ischemia in anesthetized rats and compared with those of diltiazem. "
|2.||Calcium Channels (Calcium Channel)
|9.||Methacholine Chloride (Methacholine)
|2.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)