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N-gamma-glutamylcysteine ethyl ester

Also Known As:

Glu-Cys-OEt; N-gamma-L-glutamyl-L-cysteine ethyl ester; gamma-GCE; gamma-glutamylcysteinylethyl ester

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - N-gamma-glutamylcysteine ethyl ester: 4

Experts

1.	Dobashi, Kunio: 1 article (09/2007)
2.	Hamuro, Junji: 1 article (09/2007)
3.	Hisada, Takeshi: 1 article (09/2007)
4.	Ishizuka, Tamotsu: 1 article (09/2007)
5.	Koike, Yoko: 1 article (09/2007)
6.	Mori, Masatomo: 1 article (09/2007)
7.	Murata, Yukie: 1 article (09/2007)
8.	Ono, Akihiro: 1 article (09/2007)
9.	Shimizu, Yasuo: 1 article (09/2007)
10.	Utsugi, Mitsuyoshi: 1 article (09/2007)

Related Diseases

1.	Infections 05/01/1998 - "Repressive effects of gamma-GCE on acute HIV-1 infection in human primary human peripheral blood mononuclear cells were also demonstrated. " 05/01/1998 - "Relatively high doses of gamma-GCE, utilized in acute HIV-1 infection of T-lymphocytic cells, entirely blocked the propagation of HIV-1 and rescued the cells from HIV-1-induced cell death. " 05/01/1998 - "In initial studies using a vigorously HIV-1-producing human T-lymphocytic cell line, gamma-GCE displayed a novel biphasic repressive effect on chronic HIV-1 infection that was unlike that of other glutathione prodrugs or other reported antioxidants. "
2.	Neoplasms (Cancer) 06/01/2000 - "International Cancer Research transgenic mouse males and matched (ie same strain, sex, and age) control nontransgenic mice were pretreated ip with GSH synthetase substrate gamma-glutamylcysteinyl ethyl ester (gamma-GCE) or with saline. "
3.	Cataract (Cataracts) 03/01/1991 - "The present results indicate that the administration of gamma-GCE in solution or in liposomes inhibits diabetic cataract formation, possibly by preventing lens GSH depletion." 03/01/1991 - "Instillation of gamma-GCE in solution or liposomes to STZ-diabetic rats not only inhibited cataract formation but also kept lens GSH level almost at the control level. " 03/01/1991 - "[The inhibitory effect of gamma-glutamylcysteinylethyl ester (gamma-GCE) instillation on experimental diabetic cataract formation in rats]." 03/01/1991 - "The effect of the instillation of gamma-glutamylcysteinylethyl ester (gamma-GCE), which has been reported to function as a precursor of glutathione, on cataract formation was examined in rats in which diabetes had been induced by Streptozotocin (STZ). "
4.	Body Weight (Weight, Body) 03/01/1991 - "treatment with 50 mg/kg body weight of STZ, male Wistar rats aged 6 weeks received instillations of gamma-GCE in solution or liposomes prepared with dipalmitoylphosphatidylcholine (DPPC) for a period of 9 weeks. "
5.	Asthma (Bronchial Asthma) 09/01/2007 - "In the mouse asthma model, intraperitoneal injection of gamma-GCE elevated the GSH/GSSG ratio of lung tissue and reduced AHR. " 09/01/2007 - "Taken together, these findings suggest that changing glutathione redox balance, increase in GSH level, and the GSH/GSSG ratio by gamma-GCE, ameliorate bronchial asthma by altering the Th1/Th2 imbalance through IL-12 production from APC and suppressing chemokine production and eosinophil migration itself."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Prodrugs
3.	Antioxidants
4.	N-gamma-glutamylcysteine ethyl ester
5.	Glutathione Disulfide (GSSG)
6.	Chemokines
7.	Interleukin-12 (IL 12)
8.	1,2-Dipalmitoylphosphatidylcholine (Dipalmitoylphosphatidylcholine)
9.	Streptozocin (Streptozotocin)
10.	Solutions

Related Therapies and Procedures

1.	Intraperitoneal Injections