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1,3,4-thiadiazol-2-ylcyanamide

effective against influenza A & B viruses; structure given in first source; RN givenrefers to the Na-salt; RN for parent cpd not available 5/91
Also Known As:
LY 217896; LY 253963; LY-217896; LY-253963; LY217896; LY253963
Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Human Influenza (Influenza)
07/01/1990 - "The compound LY253963 (1,3,4-thiadiazol-2-ylcyanamide) inhibited the in vitro replication of representative influenza A and B viruses in Madin-Darby canine kidney (MDCK) cells at concentrations of 1-3.2 micrograms/ml. The yield of an influenza A (H3N2) virus in primary rhesus monkey kidney (RMK) cells was inhibited at 0.1-0.3 micrograms/ml. However, similar concentrations were inhibitory for the growth of uninfected MCDK or RMK cells. "
11/01/1990 - "LY217896 (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus. "
05/01/1994 - "The efficacy and safety of oral LY217896 for prevention of experimental influenza A/Kawasaki/86 (H1N1) virus infection were assessed in susceptible males randomly assigned to receive LY217896 (75 mg) or placebo once daily for 7 days beginning 24 h prior to viral challenge. "
05/01/1994 - "LY217896 was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection."
07/01/1990 - "Virus-specific protein synthesis was inhibited to a greater extent by ribavirin 10 micrograms/ml or rimantadine 1 microgram/ml than by LY253963 10 micrograms/ml. No drug-resistant mutants were detected during serial passage of an influenza A (H3N2) virus in the presence of LY253963 1-16 micrograms/ml. In summary, we found that LY253963 inhibited influenza A and B virus replication in several cell types, but that it was associated with cytostatic effects at low concentrations. "
2. Paramyxoviridae Infections (Parainfluenza)
3. Fever (Fevers)
4. Infection

Related Drugs and Biologics

1. 1,3,4-thiadiazol-2-ylcyanamide
2. Sodium
3. Hemagglutinins (Hemagglutinin)
4. Uric Acid (Urate)
5. Rimantadine
6. Ribavirin (Virazole)

Related Therapies and Procedures

1. Intraperitoneal Injections