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Setipafant

platelet activating factor antagonist

Also Known As:

BN 50727; BN-50727

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - Thienopyridines: 211
      - Setipafant: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - Thienopyridines: 211
      - Setipafant: 3
  - Pyridines: 88
    - Thienopyridines: 211
      - Setipafant: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Thienopyridines: 211
      - Setipafant: 3

Related Diseases

1.	Ischemia 12/01/1996 - "The aim of this study was to evaluate the role of PAF in the perpetuation and aggravation of gastrointestinal damage resulting from limited ischemia in the 2-day-old piglet using a natural PAF antagonist (BN 50727). " 12/01/1996 - "Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets."
2.	Necrotizing Enterocolitis 12/01/1996 - "Macroscopic and histological lesions of intestinal wall in groups I4, I9, IT4 and IT9 were similar to those of human neonatal necrotizing enterocolitis and did not vary according to the absence or the presence of BN 50727 treatment (P = .7, I4 v IT4 and P = .9, I9 v IT9). "
3.	Thrombosis (Thrombus) 01/01/1992 - "Specific PAF-acether-antagonists, such as BN 52021 a ginkgolide, but also synthetic molecules, derivatives of the triazolo-pyridino-diazepine group (BN 50727, BN 50755 and BN 50789), significantly inhibit platelet-vessel wall interactions and thrombosis, but not the formation of blebs in the endothelial cells. "
4.	Blister (Bulla) 01/01/1992 - "Specific PAF-acether-antagonists, such as BN 52021 a ginkgolide, but also synthetic molecules, derivatives of the triazolo-pyridino-diazepine group (BN 50727, BN 50755 and BN 50789), significantly inhibit platelet-vessel wall interactions and thrombosis, but not the formation of blebs in the endothelial cells. "
5.	Crystal Arthropathies 01/01/1996 - "In a rabbit model of acute crystal arthritis, we have compared the anti-inflammatory effect of two new molecules: BN 50727 with anti-PAF activity, and BN 50548 an inhibitor of PMN proteinases. " 01/01/1996 - "In conclusion, BN 50727 and BN 50548, two compounds with PAF antagonist and antiproteinase activity, respectively exert an anti-inflammatory effect in an experimental model of acute urate crystal arthritis, probably due to a decrease in TNF alpha and IL-6 synthesis."

Related Drugs and Biologics

1.	Platelet Activating Factor
2.	Ginkgolides
3.	Interleukin-6 (Interleukin 6)
4.	Uric Acid (Urate)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Peptide Hydrolases (Proteases)
7.	BN 50548
8.	ginkgolide B