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endothelium-dependent hyperpolarization factor (EDHF)

may be related to anandamide; released from endothelium of rat pulmonary arteries; nonprostanoid, nonidentified factor that contributes to endothelium-dependent relaxation by causing hyperpolarization of the vascular smooth muscle
Also Known As:
EDHF; endothelium-derived hyperpolarization factor
Networked: 152 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. He, Guo-Wei: 9 articles (01/2014 - 09/2002)
2. Yang, Qin: 6 articles (01/2014 - 09/2002)
3. Yim, Anthony P C: 6 articles (01/2007 - 09/2002)
4. Shimokawa, Hiroaki: 5 articles (01/2015 - 05/2005)
5. Goto, Kenichi: 5 articles (08/2009 - 07/2004)
6. Buikema, Hendrik: 5 articles (02/2009 - 03/2003)
7. Bełtowski, Jerzy: 4 articles (01/2014 - 05/2006)
8. de Zeeuw, Dick: 4 articles (02/2009 - 03/2003)
9. Fujii, Koji: 4 articles (02/2006 - 10/2002)
10. Jamroz-Wiśniewska, Anna: 3 articles (01/2014 - 05/2006)

Related Diseases

1. Ischemia
07/01/2009 - "EDHF was likely the sole mediator responsible for the direct effects of LPC on U-46619-vasoconstriction, whereas the augmented vasoconstrictor responses following LPC washout may in part be related to an increase in ET-1, and a striking reduction in the bioavailability of NO. Our data suggest that in addition to reducing the accumulation of LPC to prevent ischemia-reperfusion (I/R) damage, efforts targeting an improved endothelium-dependent regulation of vascular tone could be an attractive approach to limit the cardiac damage induced by I/R."
01/01/2014 - "Pharmacological modulation of these channels during ischemia-reperfusion and hyperkalemic exposure show promising results on the preservation of NO and EDHF-mediated endothelial function, which suggests the potential of targeting endothelial K(+) and TRP channels for myocardial protection during cardiac surgery. "
01/01/2014 - "Hyperkalemic exposure and concurrent ischemia-reperfusion during cardioplegic intervention compromise NO and EDHF-mediated function and the impairment involves alterations of K(+) channels, that is, KATP and KCa, and Ca(2+)-permeable TRP channels in endothelial cells. "
04/01/2009 - "The preservation of EDHF responsiveness of PA after ischemia and reperfusion suggests an important role for this vasodilator under conditions when NOS is inhibited."
04/01/2009 - "The role of SK(Ca) and IK(Ca) channels in myogenic tone and endothelium-derived hyperpolarizing factor (EDHF) responsiveness was investigated under control conditions and after ischemia and reperfusion in parenchymal arterioles (PA) versus middle cerebral arteries (MCA). "
2. Hypercholesterolemia
3. Cardiovascular Diseases (Cardiovascular Disease)
4. Myocardial Infarction
5. Hypertension (High Blood Pressure)

Related Drugs and Biologics

1. Cholesterol
2. quinapril (Accupril)
3. Nitric Oxide (Nitrogen Monoxide)
4. Bradykinin
5. Nitric Oxide Synthase (NO Synthase)
6. NG-Nitroarginine Methyl Ester (L-NAME)
7. Prostaglandins
8. Nicorandil (SG 75)
9. Free Radicals
10. Type 1 Angiotensin Receptor

Related Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)
2. Ligation
3. Induced Heart Arrest (Cardioplegia)