|1.||Gates, Kent S: 3 articles (08/2014 - 10/2007)|
|2.||Anderson, Robert F: 2 articles (03/2010 - 06/2005)|
|3.||Hay, Michael P: 2 articles (03/2010 - 06/2005)|
|4.||Denny, William A: 2 articles (03/2010 - 06/2005)|
|5.||Shinde, Sujata S: 2 articles (03/2010 - 06/2005)|
|6.||Junnotula, Venkatraman: 2 articles (01/2009 - 10/2007)|
|7.||Barnes, Charles L: 1 article (08/2014)|
|8.||Parsons, Zachary D: 1 article (08/2014)|
|9.||Johnson, Kevin M: 1 article (08/2014)|
|10.||Patterson, Adam V: 1 article (03/2010)|
01/28/2009 - "The antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, TPZ, 1) gains medicinal activity through its ability to selectively damage DNA in the hypoxic cells found inside solid tumors. "
01/01/2000 - "An on-line microdialysis microbore HPLC method is described for the determination of the bioreductive anti-tumor agent, tirapazamine (3-amino-1,2,4-benzotriazine-1,4-di-N-oxide, SR4233, WIN59075, Tirazone, TPZ) and its two major reduced metabolites, 3-amino-1,2,4-benzotriazine-1-N-oxide (SR4317) and 3-amino-1,2,4-benzotriazine (SR4330). "
01/01/1992 - "SR 4233 was also reduced by the rat tumor enzyme predominantly via 4e reduction to the benzotriazine SR 4330, in a novel reaction mechanism. "
12/15/1990 - "The new bioreductive drug 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR 4233) shows a high selective cytotoxicity for hypoxic cells, both in vitro and in tumors in vivo. "
10/24/2007 - "The compound 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, TPZ) is a clinically promising anticancer agent that selectively kills the oxygen-poor (hypoxic) cells found in solid tumors. "
06/07/2005 - "Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides."
03/03/2010 - "Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)."
11/01/1996 - "The one-electron reduction potential of 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine): a hypoxia-selective bioreductive drug."
08/15/2014 - "Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)."
|1.||tirapazamine (SR 4233)
|4.||DNA (Deoxyribonucleic Acid)