|1.||Patil, Bhimanagouda S: 8 articles (03/2015 - 04/2005)|
|2.||Jayaprakasha, Guddadarangavvanahally K: 4 articles (03/2015 - 06/2011)|
|3.||Jayaprakasha, G K: 2 articles (10/2014 - 07/2011)|
|4.||Kim, Jinhee: 2 articles (10/2014 - 02/2013)|
|5.||Harris, Edward D: 2 articles (01/2006 - 04/2005)|
|6.||Poulose, Shibu M: 2 articles (01/2006 - 04/2005)|
|7.||Wada, K: 2 articles (01/2001 - 01/2000)|
|8.||Miyake, M: 2 articles (01/2001 - 01/2000)|
|9.||Tanaka, T: 2 articles (01/2001 - 01/2000)|
|10.||Kohno, H: 2 articles (01/2001 - 01/2000)|
01/01/2000 - "In a subsequent long-term experiment (38 weeks), in which rats were initiated with AOM and fed 0.05% obacunone or 0.05% limonin during the initiation or post-initiation phase, both compounds in diet caused significant reduction (65%-92% inhibition) in the incidence of colonic adenocarcinoma. "
01/01/2001 - "Obacunone or limonin feeding during the post-initiation phase also reduced the frequency of colonic adenocarcinoma (72 versus 13%, P = 0.0002). "
01/01/2001 - "At the termination of the study, dietary exposure to obacunone or limonin during the initiation phase was found to have significantly reduced the incidence of colonic adenocarcinoma (72 versus 25 or 6%, P = 0.004 or 0.00003). "
10/01/2014 - "Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells."
10/01/2014 - "Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. "
07/28/2004 - "In the second experiment, obacunone reduced tumor number and burden by 25 and 40%, respectively, whereas deoxylimonin reduced tumor number and burden by 30 and 50%, respectively. "
01/01/2006 - "Viability, as quantified by 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyltetrazolium reduction and light microscopy, was shortened significantly (P < 0.001) in cancer cells exposed to aglycones, viz., limonin, nomilin, obacunone, and deacetylnomilin. "
01/01/2001 - "The primary objective of this study was to test the antiproliferative activity of limonoids (obacunone 17 beta-D-glucopyranoside, nomilinic acid 17 beta-D-glucopyranoside, limonin, nomilin, and a limonoid glucoside mixture), found in high concentrations in mandarin (Citrus reticulata Blanco), against a series of human cancer cell lines. "
07/28/2004 - "Using the hamster cheek pouch model, three new limonoids (ichangensin, deoxylimonin, and obacunone) have now been tested for cancer chemopreventive activity. "
|3.||Colonic Neoplasms (Colon Cancer)
07/01/2011 - "Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis."
07/01/2011 - "The study was aimed to purify obacunone and obacunone glucoside (OG) from seeds of Marsh White grapefruit and understand the mode of cytotoxicity of limonoids on colon cancer (SW480) cells. "
01/01/2001 - "Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers."
|4.||Breast Neoplasms (Breast Cancer)
10/01/2014 - "Finally, the uptake level of obacunone into MCF-7 cells was measured by HPLC and its structure was confirmed by LC-HR-MS. This study demonstrated that obacunone may have the potential to prevent estrogen-responsive breast cancer through inhibition of the aromatase enzyme and inflammatory pathways, as well as activation of apoptosis. "
10/01/2014 - "Exposure of MCF-7 breast cancer cells to obacunone down-regulated expression of inflammatory molecules including nuclear factor-kappa B (NF-κB) and cyclooxygenase-2 (COX-2). "
02/01/2013 - "A panel of 9 purified limonoids, including limonin, nomilin, obacunone, limonexic acid (LNA), isolimonexic acid (ILNA), nomilinic acid glucoside (NAG), deacetyl nomilinic acid glucoside (DNAG), limonin glucoside (LG) and obacunone glucoside (OG) as well as 4 modified compounds such as limonin methoxime (LM), limonin oxime (LO), defuran limonin (DL), and defuran nomilin (DN), were screened for their cytotoxicity on estrogen receptor (ER)-positive (MCF-7) or ER-negative (MDA-MB-231) human breast cancer cells. "
|5.||Prostatic Neoplasms (Prostate Cancer)
03/02/2015 - "The results of this study provided, for the first time, an evidence of the cytotoxicity of obacunone and OG in androgen-dependent human prostate cancer cells."
03/02/2015 - "The current study reports the mechanism of cytotoxicity of citrus-derived obacunone and OG on human androgen-dependent prostate cancer LNCaP cells. "
03/02/2015 - "Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death."
|7.||Cyclooxygenase 2 (Cyclooxygenase-2)
|8.||p38 Mitogen-Activated Protein Kinases
|9.||Prostate-Specific Antigen (Semenogelase)
|10.||NF-kappa B (NF-kB)