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trapoxin A

from Helicoma ambiens; structure given in first source
Also Known As:
cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl); trapoxin
Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Shindoh, Nobuaki: 1 article (01/2008)
2. Kao, Jeff: 1 article (01/2008)
3. Wu, Yun: 1 article (01/2008)
4. Arbor, Sage: 1 article (01/2008)
5. Marshall, Garland R: 1 article (01/2008)
6. Masuoka, Yuhta: 1 article (01/2008)
7. Inamura, Noriaki: 1 article (01/2008)
8. Wang, Shaowen: 1 article (09/2003)
9. Zeremski, Marija: 1 article (09/2003)
10. Cai, Richard: 1 article (09/2003)

Related Diseases

1. Neoplasms (Cancer)
12/03/1999 - "In this study, treatment of human tumor cells with the histone deacetylase inhibitor, trapoxin (TPX), resulted in selective changes in genes that control the cell cycle. "
01/01/2008 - "Recently, HDAC inhibitors have been focused on as potential drugs for the treatment of several diseases, including cancer, although trichostatin A and trapoxin show no effects in animal models because of their metabolic instability in vivo. "
09/18/2003 - "Much of our current understanding of this transcriptional control comes from the use of HDAC inhibitors such as trapoxin A (TPX), which leads to hyperacetylated histone, alters local chromatin architecture and transcription and results in tumor cell death. "
01/01/2008 - "Naturally occurring cyclic tetrapeptides (CTPs) such as tentoxin (Halloin et al., Plant Physiol 1970, 45, 310-314; Saad, Phytopathology 1970, 60, 415-418), ampicidin (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147), HC-toxin (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447), and trapoxin (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328; Itazaki et al., J Antibiot (Tokyo) 1990, 43, 1524-1532) have a wide range of biological activity and potential use ranging from herbicides (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447; Judson, J Agric Food Chem 1987, 35, 451-456) to therapeutics (Loiseau, Biopolymers 2003, 69, 363-385) for malaria (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147) and cancer (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328). "
2. Peripheral Primitive Neuroectodermal Tumors (Peripheral Neuroectodermal Tumor)
3. Malaria
4. Leukemia

Related Drugs and Biologics

1. Histone Deacetylase Inhibitors
2. trichostatin A (A 300)
3. Histones (Histone)
4. Histone Deacetylases (Histone Deacetylase)
5. Herbicides
6. Chromatin
7. Choline O-Acetyltransferase (Choline Acetyltransferase)
8. Butyrates (Butyrate)
9. Biopolymers
10. chlorotriphenylsilane (CTPS)

Related Therapies and Procedures

1. Therapeutics